18051-18-8 Usage
Description
(+)-6-Methylergoline-8β-acetonitrile is a chemical compound that belongs to the ergoline alkaloid group. It is a derivative of ergoline and is a precursor to the neurotransmitter dopamine. (+)-6-Methylergoline-8β-acetonitrile has been studied for its potential use as a dopaminergic agent and has been investigated for its pharmacological properties. It has also been used in the synthesis of other related compounds. The chemical structure of (+)-6-Methylergoline-8β-acetonitrile contains a six-membered ring with a nitrogen atom, which gives it its unique properties and potential biological activity. Further research is needed to fully understand the potential applications and effects of this compound.
Uses
Used in Pharmaceutical Industry:
(+)-6-Methylergoline-8β-acetonitrile is used as a dopaminergic agent for its potential therapeutic effects on neurological disorders related to dopamine imbalances. Its ability to modulate dopamine levels makes it a promising candidate for the treatment of conditions such as Parkinson's disease and schizophrenia.
Used in Chemical Synthesis:
(+)-6-Methylergoline-8β-acetonitrile is used as a precursor in the synthesis of other related compounds, contributing to the development of new pharmaceuticals and chemical products with potential applications in various industries.
Used in Research and Development:
(+)-6-Methylergoline-8β-acetonitrile is utilized in research settings to study its pharmacological properties and potential applications in medicine and other fields. Its unique chemical structure and biological activity make it an interesting subject for further investigation and development.
Check Digit Verification of cas no
The CAS Registry Mumber 18051-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,0,5 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18051-18:
(7*1)+(6*8)+(5*0)+(4*5)+(3*1)+(2*1)+(1*8)=88
88 % 10 = 8
So 18051-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N3/c1-20-10-11(5-6-18)7-14-13-3-2-4-15-17(13)12(9-19-15)8-16(14)20/h2-4,9,11,14,16,19H,5,7-8,10H2,1H3/t11-,14?,16-/m1/s1
18051-18-8Relevant articles and documents
Synthesis and antihypertensive activity of 2,4-dioxoimidazolidin-1-yl and perhydro-2,4-dioxopyrimidin-1-yl ergoline derivatives
Mantegani, Sergio,Brambilla, Enzo,Caccia, Carla,Chiodini, Laura,Ruggieri, Daniela,Lamberti, Ernesto,Di Salle, Enrico,Salvati, Patricia
, p. 293 - 304 (1998)
The synthesis and antihypertensive activity of a series of 2,4-dioxoimidazoldin-1-yl and perhydro-2,4-dioxopyrimidin-1-yl ergoline derivatives are reported. The oral antihypertensive activity was studied in spontaneously hypertensive rats (SHRs) by measuring systolic blood pressure by an indirect tail-cuff method at different times after treatment. The prolactin lowering activity (indirectly measured by the nidation test) in rats and the oral acute toxicity in mice were also studied. The results of this study revealed potent antihypertensive ergoline derivatives devoid of side-effects related to the dopaminergic stimulation and the importance of the Δ9,10 double bond for conferring high potency within these compounds.
