18059-10-4

Basic information

• Product Name: Peiminine
• Synonyms: PEIMININE;PEINININE;RADDEANINE;3beta,20-Dihydroxy-5alpha-cevan-6-one;Cevan-6-one,3,20-dihydroxy-, (3β,5α)-;Fritillarine;Osnovanine;PEIMINE (RG)
• CAS NO: 18059-10-4
• Molecular Formula: C27H43NO3
• Molecular Weight: 429.64
• Product Categories: Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 18059-10-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 267°
• Boiling Point: 567.1 °C at 760 mmHg
• Flash Point: 296.8 °C
• Appearance: /
• Density: 1.18 g/cm³
• Refractive Index: 1.585
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated)
• PKA: 14.56±0.70(Predicted)
• CAS DataBase Reference: Peiminine(CAS DataBase Reference)
• NIST Chemistry Reference: Peiminine(18059-10-4)
• EPA Substance Registry System: Peiminine(18059-10-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 18059-10-4(Hazardous Substances Data)

Usage

Description

Peiminine is a natural product derived from the Fritillaria species of medicinal plants, specifically Fritillaria anhuiensis and Fritillaria ebeiensis. It is a steroidal alkaloid compound with potent anti-inflammatory, antitussive, and expectorant effects. Peiminine has been found to induce autophagic cell death, which helps in repressing the growth of colorectal carcinoma tumors. The structure of Peiminine has been determined through chemical analysis and the examination of ultraviolet, infrared, NMR, and mass spectra.

Uses

1. Used in Pharmaceutical Applications:
Peiminine is used as an anti-inflammatory agent for its potent anti-inflammatory effects, which can help in reducing inflammation in various conditions.
Peiminine is used as an antitussive agent for its ability to suppress coughing, making it useful in treating conditions associated with excessive coughing.
Peiminine is used as an expectorant agent for its effectiveness in promoting the removal of mucus from the respiratory system, aiding in the treatment of respiratory disorders.
2. Used in Anticancer Applications:
Peiminine is used as an anticancer agent for its ability to induce autophagic cell death, which helps in repressing the growth of colorectal carcinoma tumors.
3. Used in Chemical Research:
Peiminine serves as a valuable compound for chemical research due to its unique structure and properties. It can be used in the study of alkaloid chemistry, natural product chemistry, and the development of new drugs based on its structure and biological activities.

References

Kametani et al., Heterocycles, 4, 723 (1976)

InChI:InChI=1/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23-,25-,26+,27-/m0/s1

Upstream product

• 77410-35-6 C₂₇H₄₃NO₄ 

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