18075-64-4

Basic information

• Product Name: 1-Phenyl-1H-imidazole-4-carboxylic acid
• Synonyms: 1-Phenyl-1H-imidazole-4-carboxylic acid
• CAS NO: 18075-64-4
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.185
• Mol File: 18075-64-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 424.516°C at 760 mmHg
• Flash Point: 210.54°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.48±0.10(Predicted)
• CAS DataBase Reference: 1-Phenyl-1H-imidazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-1H-imidazole-4-carboxylic acid(18075-64-4)
• EPA Substance Registry System: 1-Phenyl-1H-imidazole-4-carboxylic acid(18075-64-4)

Safety Data

• Hazardous Substances Data: 18075-64-4(Hazardous Substances Data)

Usage

General Description

1-Phenyl-1H-imidazole-4-carboxylic acid, also known as PHICA, is a heterocyclic organic compound with a chemical structure containing both an imidazole ring and a carboxylic acid group. It is a white crystalline powder that is soluble in polar solvents, and it has potential applications in the field of medicine and pharmaceuticals. PHICA has been studied for its potential as an anti-inflammatory and antimicrobial agent, and it also has potential use in the synthesis of other organic compounds. Additionally, PHICA derivatives have been investigated for their potential as anticancer agents. Overall, 1-Phenyl-1H-imidazole-4-carboxylic acid is a versatile chemical with potential applications in various fields.

InChI:InChI=1/C10H8N2O2/c13-10(14)9-6-12(7-11-9)8-4-2-1-3-5-8/h1-7H,(H,13,14)

Upstream product

• 116343-89-6 methyl 1-phenyl-1H-imidazole-4-carboxylate 
• 197079-08-6 ethyl 1-phenyl-1H-imidazole-4-carboxylate 
• 591-50-4 iodobenzene 
• 103-70-8 Formanilid 
• 1197040-29-1 phenyl isocyanate 
• 62-53-3 aniline 

Downstream Products

• 1188373-49-0 1-phenyl-1H-imidazole-4-carboxylic acid {2-oxo-2-[4-(3-trifluoromethylphenoxy)piperidin-1-yl]ethyl}amide 
• 1188373-50-3 1-phenyl-1H-imidazole-4-carboxylic acid {2-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-2-oxoethyl}amide 
• 1188373-85-4 1-phenyl-1H-imidazole-4-carboxylic acid {2-[4-(2,5-difluorophenoxy)piperidin-1-yl]-2-oxoethyl}amide 
• 1232028-07-7 1-phenyl-1H-imidazole-4-carboxylic acid {2-[4-(2-chloro-5-fluoro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-amide 
• 1391625-85-6 (3S,6S)-3,6-diisobutyl-4-(1-phenyl-1H-imidazole-4-carbonyl)-piperazin-2-one 
• 1613022-33-5 C₂₁H₂₀N₆O*C₂HF₃O₂ 
• 1613022-32-4 1-phenyl-1H-imidazole-4-carboxylic acid (1-pyrrolo[1,2-a]pyrazin-1-yl-pyrrolidin-3-yl)amide 
• 1613022-35-7 1-phenyl-1H-imidazole-4-carboxylic acid[1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613021-87-6 (S)-N-(1-([1,2,4]triazolo[4,3-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-phenyl-1H-imidazole-4-carboxamide 

Relevant articles and documents

4-phenoxyl substituted quinoline compound containing 2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one and imidazole and application of compound

The invention relates to a quinoline derivative shown as the general formula I and containing 2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one and imidazole, and pharmaceutically acceptable salt, hydrate, solvate or prodrug of the quinoline derivative. In the general formula I, Ar, R1, R2, L, and n have meanings as the description defined. The invention further relates to a great c-Met kinase inhibiting effect of the compound shown as the general formula I, and applications of pharmaceutically acceptable salt, hydrate, solvate or prodrug of the compound to prepare medicines for treating and/or preventing diseases caused by abnormal high expression of c-Met kinase, particularly an application of preparing a medicine for treating and/or preventing cancer.

Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies

The synthesis and structure-activity relationship studies of imidazoles are described. The target compounds 6-20 represent a novel chemotype of potent and CB2/CB1 selective cannabinoid CB2 receptor antagonists/inverse agonists with very high binding efficiencies in combination with favourable log P and calculated polar surface area values. Compound 12 exhibited the highest CB2 receptor affinity (Ki = 1.03 nM) in this series, as well as the highest CB2/CB1 subtype selectivity (>9708-fold).

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.