1808-12-4 Usage
Description
Bromodiphenhydramine Hydrochloride (200 MG) is a histamine H1 receptor antagonist that functions as an antihistaminic. It is a white to pale buff crystalline powder, freely soluble in water and alcohol, and is more lipid soluble than diphenhydramine. This increased lipid solubility makes it twice as effective in protecting against the lethal effects of histamine aerosols.
Uses
Used in Pharmaceutical Industry:
Bromodiphenhydramine Hydrochloride (200 MG) is used as an antihistaminic for controlling cutaneous allergies. It is effective in preventing histamine release in isolated guinea pig lung and inhibits formalin-induced paw edema in rats. Additionally, it increases survival in a mouse model of systemic S. typhimurium infection.
Used in Allergy Treatment:
Bromodiphenhydramine Hydrochloride (200 MG) is used as an antihistamine to treat various allergic reactions, such as skin rashes, itching, and swelling. Its ability to block histamine H1 receptors helps alleviate allergy symptoms and provide relief to patients.
Used in Antimicrobial Applications:
Bromodiphenhydramine Hydrochloride (200 MG) is used as an antimicrobial agent, exhibiting properties that help control the growth of certain microorganisms. This makes it useful in treating infections and preventing the spread of harmful bacteria.
Check Digit Verification of cas no
The CAS Registry Mumber 1808-12-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,0 and 8 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1808-12:
(6*1)+(5*8)+(4*0)+(3*8)+(2*1)+(1*2)=74
74 % 10 = 4
So 1808-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
1808-12-4Relevant articles and documents
Anti-inflammatory effects of two new methyl and morpholine derivatives of diphenhydramine on rats
Ahmadi, Abbas,Khalili, Mohsen,Hajikhani, Ramin,Safari, Narjes,Nahri-Niknafs, Babak
, p. 3532 - 3540 (2013/02/25)
Diphenhydramines are one of the first-generation histamine H1-receptor antagonists of the ethanolamine class that demonstrate many pharmacological properties including anti-inflammatory effects. In this research, bromo (II) and two new tolyl derivatives of I, (Di [p-tolyl] [dimethylaminoethoxy] methane, III) and (Di [p-tolyl] [2-morpholinoethoxy] methane, IV) were synthesized. Their acute and chronic anti-inflammatory activities were evaluated with the formalin and histamine-induced rat paw edema. The vascular permeability in formalin and histamine-induced paw edema, in xylene-induced ear edema, and in peritonitis after acetic acid application into peritoneal cavity were also measured and compared to II. Cotton pellet-induced granuloma model was selected for inducing chronic inflammations in rats. The newly synthesized analogs of diphenhydramine seemed effective to decrease acute inflammations. It was concluded that the prominent anti-phlogistic effects of the new drugs could be related to its reduction vascular permeability mechanism(s) or to its antagonistic effects on H1 histamine receptors. Springer Science+Business Media, LLC 2011.
