18087-10-0

Basic information

• Product Name: 4,5-Dimethyl-2-nitrophenol
• Synonyms: 4,5-Dimethyl-2-nitrophenol;4,5-Dimethyl-2-hydroxynitrobenzene, 4-Hydroxy-5-nitro-o-xylene
• CAS NO: 18087-10-0
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16196
• Mol File: 18087-10-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 281.6°C at 760 mmHg
• Flash Point: 124.4°C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 0.00207mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 4,5-Dimethyl-2-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dimethyl-2-nitrophenol(18087-10-0)
• EPA Substance Registry System: 4,5-Dimethyl-2-nitrophenol(18087-10-0)

Safety Data

• Hazardous Substances Data: 18087-10-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9NO3/c1-5-3-7(9(11)12)8(10)4-6(5)2/h3-4,10H,1-2H3

Upstream product

• 95-65-8 3,4-Dimethylphenol 
• 540-80-7 tert.-butylnitrite 
• 700-38-9 2-nitro-5-methylphenol 
• 3845-63-4 3,4-dimethylphenyl benzoate 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 196494-43-6 2-benzoyloxy-4,5-dimethylnitrobenzene 
• 32590-94-6 3,4-dimethyl-4-nitrocyclohexa-2,5-dienone 

Downstream Products

• 18087-11-1 4,5-dimethyl-2-nitro-anisole 
• 459841-21-5 4-(2-nitro-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester 
• 151293-11-7 5,6-dimethyl-2-phenylbenzo[d]oxazole 
• 310414-52-9 5-amino-2-(5,6-dimethylbenzo[d]oxazol-2-yl)phenol 
• 856806-20-7 4-methoxy-5-nitro-phthalic acid dimethyl ester 
• 408339-12-8 4-methoxy-5-nitro-phthalic acid 
• 40318-31-8 3,4-dimethyl-2,6-dinitroaniline 
• 125065-84-1 4-hydroxy-3,4-dimethyl-2,6-dinitrocyclohexa-2,5-dienone 
• 196494-54-9 3-(2-hydroxy-4,5-dimethylphenylamino)-1,1,4,4-tetramethyltetralin-2-one 
• 196494-45-8 N-(2-hydroxy-4,5-dimethylphenyl)-4-methylbenzenesulfonamide 
• 160582-52-5 7-benzyloxy-6-chloro-4,5-dimethylisatin 
• 253268-21-2 2'-benzyloxy-3'-chloro-4',5'-dimethylisonitrosoacetanilide 
• 160582-53-6 3-benzyloxy-4-chloro-5,6-dimethylanthranilic acid 
• 160582-66-1 2-benzyloxy-3-chloro-4,5-dimethyl-1-nitrobenzene 

Relevant articles and documents

Nitration method for aryl phenol or aryl ether derivative

The invention relates to a nitration method for an aryl phenol or aryl ether derivative. The method comprises the steps of stirring an aryl phenol or aryl ether compound, nitrate, trimethylchlorosilane (TMSCl) and a copper salt in an acetonitrile solution in air at room temperature, simultaneously, monitoring extent of reaction through a TLC dot plate, removing a solvent from a mixture by a rotaryevaporator after a substrate is consumed completely, and carrying out purification through a silica-gel column, thereby obtaining a nitroolefin derivative. Meanwhile, the selective mono-nitration orbis-nitration of the substrate can be achieved through controlling equivalent weight of the nitrate. Compared with the prior art, the nitration method disclosed by the invention has the advantages that the consumption of strong-acid substances is avoided, the reaction conditions are mild, the yield is high, the applicable range of the substrate is wide, reaction activity is free of obvious attenuation after an amplified reaction, and an excellent yield is still obtained, so that the method has an obvious industrial application value.

Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of duchenne muscular dystrophy

Figure Presented. A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential treatment for Duchenne muscular dystrophy. Following the delineation of structure-activity relationships in the series, a number of potent upregulators were identified, and preliminary ADME evaluation is described. These studies have resulted in the identification of 1, a compound that has been progressed to clinical trials.

Nitration of substituted phenols by different efficient heterogeneous systems

Nitration of substituted phenols were carried out by the mixture of sodium nitrite and wet SiO2 (50% w/w) in the presence of four different efficient heterogeneous systems: 1) oxalic acid dihydrate (I), 2) sodium hydrogen sulphate (II), 3) aluminum hydrogen sulphate (III) and 4) silica sulphuric acid (IV) in CH2Cl2 at room temperature and high yields. Optimum conditions for theses systems and the regioselectivities of the reactions are reported.