18087-65-5

Basic information

• Product Name: 1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonsaeure-methylester
• Synonyms: 1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonsaeure-methylester
• CAS NO: 18087-65-5
• Molecular Weight: 284.142
• Mol File: 18087-65-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonsaeure-methylester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonsaeure-methylester(18087-65-5)
• EPA Substance Registry System: 1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonsaeure-methylester(18087-65-5)

Safety Data

• Hazardous Substances Data: 18087-65-5(Hazardous Substances Data)

Upstream product

• 103301-78-6 1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 

Downstream Products

• 106116-09-0 L-5-Oxo-1-(trimethylsilyl)prolin-benzylester 
• 94885-52-6 benzyl (L)-pyroglutamate 
• 106116-10-3 L-1-Benzhydryl-5-oxoprolin-benzylester 
• 100-51-6 benzyl alcohol 
• 18087-66-6 1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonsaeure 

Relevant articles and documents

Amino Acids, 9 - Reactions of 5-Oxoproline Derivatives with Phosphorus Pentachloride - Synthesis of Chloro-pyrrole-2-carboxylic Acid Derivatives

N-Benzyl-4,5-dichloro-1H-pyrrole-2-carboxylic esters 6 are formed from N-benzyl-5-oxoproline esters 5 and PCl5 via differently chlorinated intermediates.The N-benzhydryl- L-3 and N-acyl-5-oxoproline esters L-4, on the other hand, suffer cleavage of the N-substituent in the course of this reaction sequence to give L-4,4,5-trichloro-3,4-dihydro-2H-pyrrole-2-carboxylic esters 18, which are dehydrohalogenated in the presence of base, yielding 4,5-dichloro-1H-pyrrole-2-carboxylic esters 20.These reactions provide the best access to 4,5-dichloro-1H-pyrrole-2-carboxylic acid derivatives which, in turn, can serve as precursors in the synthesis of pyoluteorin type compounds.