1809-21-8

Basic information

• Product Name: DIPROPYL PHOSPHITE
• Synonyms: DIPROPYL PHOSPHITE;di-n-Propylphosphite;phosphonicaciddipropylester;dipropyl phosphonate;DIPROPYLPHOSPHITE,97%
• CAS NO: 1809-21-8
• Molecular Formula: C₆H₁₅O₃P
• Molecular Weight: 166.16
• EINECS: 217-318-2
• Mol File: 1809-21-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 203 °C(lit.)
• Flash Point: 96 °C
• Appearance: /
• Density: 1.018 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.405mmHg at 25°C
• Refractive Index: n20/D 1.417(lit.)
• CAS DataBase Reference: DIPROPYL PHOSPHITE(CAS DataBase Reference)
• NIST Chemistry Reference: DIPROPYL PHOSPHITE(1809-21-8)
• EPA Substance Registry System: DIPROPYL PHOSPHITE(1809-21-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• Hazardous Substances Data: 1809-21-8(Hazardous Substances Data)

Usage

General Description

Dipropyl phosphite is a chemical compound with the molecular formula C6H15O3P. It is a clear, colorless liquid with a slightly fruity odor. It is primarily used as a flame retardant in various materials, such as plastics and synthetic fibers, to improve their fire resistance. It serves as a processing aid in the production of polyurethane and as a stabilizer in the production of PVC. Dipropyl phosphite is also used as a chemical intermediate in the synthesis of other organophosphorus compounds. It is important to handle dipropyl phosphite with care, as it can be irritating to the skin and eyes, and harmful if ingested or inhaled.

InChI:InChI=1/C6H15O3P/c1-3-5-8-10(7)9-6-4-2/h10H,3-6H2,1-2H3

Upstream product

• 923-99-9 tri-n-propyl phosphite 
• 71-23-8 propan-1-ol 
• 762-04-9 phosphonic acid diethyl ester 
• 868-85-9 Dimethyl phosphite 
• 58498-86-5 diethyl-phosphoramidous acid dipropyl ester 
• 51761-35-4 C₇H₁₇O₅PS 
• 20003-39-8 dipropyl phosphorochloridite 
• 88351-47-7 diphosphorus (III)-oic acid tetrapropyl ester 
• 7732-18-5 water 
• 84674-96-4 C₇H₁₇O₆PS 
• 42414-50-6 dipropyl sodiophosphite 
• 302-17-0 chloral hydrate 
• 20626-99-7 methyl-phosphonothioic acid O-isobutyl ester 
• 4526-11-8 N,N-diethyl-P-methyl-phosphonamidic O,O'-dipropyl-phosphorous anhydride 

Downstream Products

• 107620-04-2 (α-hydroxy-3-nitro-benzyl)-phosphonic acid dipropyl ester 
• 19524-86-8 (α-hydroxy-benzyl)-phosphonic acid dipropyl ester 
• 106-36-5 propyl propionate 
• 6156-14-5 Octyl-phosphonsaeure-dipropylester 
• 925-15-5 dipropyl succinate 
• 26245-77-2 (PrO)2P(=O)NHC₆H₅ 
• 2315-68-6 propyl benzoate 
• 607-90-9 propyl salicylate 
• 6179-67-5 Butyl-phosphonic acid dipropyl ester 
• 6155-94-8 Heptyl-phosphonic acid dipropyl ester 
• 40468-32-4 O,O-Di-n-propyl-1-(3-chlorphenyl)-3-hydroxy-2-butenylphosphonat 
• 55369-08-9 (4-hydroxy-2,5-dimethyl-1-phenyl-phosphinan-4-yl)-phosphonic acid dipropyl ester 
• 16400-83-2 S-Propyl-isothiuronium-propylphosphit 
• 40468-42-6 O,O-Dipropyl-1-(5-brom-2-hydroxyphenyl)-3-hydroxy-2-butenylphosphonat 

Relevant articles and documents

Fluorinated phosphorus compounds: Part 11. The reactions of some fluorinated amines with dialkyl and bis(fluoroalkyl) phosphorochloridates

Dimethyl phosphorochloridate reacted with RFCH 2NH2 in ether in the presence of Et3N to afford (MeO)2P(O)NHCH2RF, where RF = CF3 and C2F5, in 39 and 47% yield, respectively. Similar reactions with di-n-propyl and diisopropyl phosphorochloridates could be effected only with H2NCH 2CF3 when 4-dimethylaminopyridine catalyst was added and (n-PrO)2P(O)NHCH2CF3 and (i-PrO) 2P(O)NHCH2CF3 were isolated in 49 and 25% yield, respectively. Treatment of POCl3 with one molar equivalent each of H2NCH2CF3 and Et3N permitted the synthesis of Cl2P(O)NHCH2CF3 in 43% yield. Bis(fluoroalkyl) phosphorochloridates (RFO)2P(O)Cl, where RF = C2F5CH2, C3F 7CH2 and (CF3)2CH, reacted with 2,2,2-trifluoroethylamine and 2,2,3,3,3-pentafluoropropylamine to furnish phosphoramidates (RFO)2P(O)NHCH2R, where R = CF3 or C2F5, in yields of 32-67%.

Method for preparing phosphite diester by transesterification

The invention discloses a method for preparing phosphite diester by transesterification. Dimethyl phosphite and monohydric alcohol which are used as raw materials are stirred, reacted and rectified under the action of a basic catalyst to prepare the phosphite diester, so the problems of high deice requirements and large amount of acid-containing three wastes in the process of producing the phosphite diester by reacting phosphorus trichloride with alcohol are avoided. The method has the advantages of low raw material toxicity, simple process, mild reaction conditions, low device requirements, low pollution, high raw material conversion rate, high product selectivity, stable supply of the raw materials, provision of the phosphite diester used for fine chemical engineering or medical intermediates by dimethyl phosphite production enterprises, high added values of the product, and provision of a new way for the synthesis of the phosphite diester.

Electrophilic trifluoromethylation of S-hydrogen phosphorothioates

A series of S-hydrogen phosphorothioates have been converted to the corresponding S-trifluoromethyl derivatives upon reaction with the electrophilic trifluoromethylation reagent 1 (trifluoromethyl 1,3-dihydro-3,3-dimethyl-1,2- benziodoxole). Relative rate data were obtained by 19F NMR monitoring of competition experiments and were evaluated by means of the Taft equation. A high positive polar sensitivity factor of 2.55 was found for electron-rich substrates and a negative one of -0.37 for electron-poor ones, implying the involvement of two different rate-determining steps. Furthermore, the reaction was found to be unaffected by steric factors.