180902-61-8

Basic information

• Product Name: 2-benzyl-2-methylbut-3-enoic acid
• CAS NO: 180902-61-8
• Molecular Weight: 190.242
• Mol File: 180902-61-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-benzyl-2-methylbut-3-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-2-methylbut-3-enoic acid(180902-61-8)
• EPA Substance Registry System: 2-benzyl-2-methylbut-3-enoic acid(180902-61-8)

Safety Data

• Hazardous Substances Data: 180902-61-8(Hazardous Substances Data)

Upstream product

• 135508-23-5 methyl 2-benzyl-2-methyl-3-oxobutanoate 
• 17094-21-2 2-methyl-acetoacetic acid methyl ester 
• 428510-41-2 methyl 2-benzyl-2-methyl-3-hydroxybutanoate 
• 80-59-1 Tiglic acid 
• 620-05-3 iodomethylbenzene 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Syntheses and kinetic evaluation of racemic and optically active 2-benzyl-2-methyl-3,4-epoxybutanoic acids as irreversible inactivators for carboxypeptidase A

Racemic and optically active 2-benzyl-2-methyl-3,4-epoxybutanoic acids were synthesized and evaluated as inactivators for carboxypeptidase A, a representative zinc-containing proteolytic enzyme. Only the threo-form of the inactivator is effective and its potency in terms of kinact/KI value is lower by 42-fold compared with 2-benzyl-3,4-epoxybutanoic acid, indicating that the α-methyl group affects adversely in the inactivation contrary to the expectation that it would enhance the inactivation activity of the inhibitor through additional interactions of the methyl group with a small cavity (α-methyl hole) present next to the S1′ hydrophobic pocket. Of the enantiomeric pair, the inactivator having the (2S,3R)-configuration is more potent than its enantiomer by 44-fold. The observed kinetic results may be rationalized on the basis that the methyl group in the inactivator having the (2R,3S)-configuration experiences the van der Waals repulsive interactions with the bottom of the active site crevice in binding to CPA, casting a doubt on the presence of the so-called α-methyl hole at the active site of carboxypeptidase A. Copyright

Alkylation of lithium dienediolates of butenoic acids. Regioselectivity effects of structure and leaving group of the alkylating agent

Regioselectivity of alkylation of but-2-enoic acids I and 2 by alkyl halides strongly depends on the reactivity of the electrophile. High α selectivity results for saturated alkyl halides, whereas poor α-selectivity is obtained for highly reactive allyl and benzyl halides. For reactive alkylating halides selectivity is partly governed by the ion pairing aggregates of the dienediolates. Lithium bromide and the carboxylate generated in the ongoing reaction cause opposite effects on regioselectivity.

Carboxy Dioxolanes as Systems for Chemical Protection and Controlled Release of Volatile Aldehydes

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