180912-08-7

Basic information

• Product Name: 4-(4-bromophenyl)-1-methyl-1,2,3,6-tetrahydropyridine
• Synonyms: 4-(4-bromophenyl)-1-methyl-1,2,3,6-tetrahydropyridine
• CAS NO: 180912-08-7
• Molecular Weight: 252.154
• Mol File: 180912-08-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-bromophenyl)-1-methyl-1,2,3,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)-1-methyl-1,2,3,6-tetrahydropyridine(180912-08-7)
• EPA Substance Registry System: 4-(4-bromophenyl)-1-methyl-1,2,3,6-tetrahydropyridine(180912-08-7)

Safety Data

• Hazardous Substances Data: 180912-08-7(Hazardous Substances Data)

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 106-37-6 1.4-dibromobenzene 
• 22480-64-4 4-bromophenyllithium 
• 139474-25-2 4-(4-bromophenyl)-1-methylpiperidin-4-ol 

Downstream Products

• 354813-48-2 methyl 4-(1-methylpiperidin-4-yl)benzoate 
• 774-52-7 1-methyl-4-phenylpiperidine 
• 1071756-46-1 C₁₃H₁₉NO 
• 1276024-93-1 (4-(1-methylpiperidin-4-yl)phenyl)carbaldehyde 
• 1100766-00-4 4-(4-bromophenyl)-1-ethoxycarbonylmethyl-1-methyl-1,2,3,6-tetrahydropyridinium chloride 

Relevant articles and documents

NOVEL INHIBITORS

The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.