18100-50-0

Basic information

• Product Name: 28-hydroxy-β-amyrone
• Synonyms: 28-hydroxy-β-amyrone
• CAS NO: 18100-50-0
• Molecular Weight: 440.71
• Mol File: 18100-50-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 28-hydroxy-β-amyrone(CAS DataBase Reference)
• NIST Chemistry Reference: 28-hydroxy-β-amyrone(18100-50-0)
• EPA Substance Registry System: 28-hydroxy-β-amyrone(18100-50-0)

Safety Data

• Hazardous Substances Data: 18100-50-0(Hazardous Substances Data)

Upstream product

• 499100-03-7 3,28-dihydroxyolean-12-ene 
• 1721-58-0 methyl 3-oxooleanolate 
• 1724-17-0 oleanolic acid methyl ester 
• 18100-49-7 3-Keto-methyl-oleanolat-ketal 
• 17990-42-0 Oleanonsaeure 
• 508-02-1 Oleanolic acid 
• 545-48-2 erythrodiol 
• 33608-08-1 3-oxoolean-12-en-28-al 

Downstream Products

• 1255647-35-8 3-oxo-28-(benzylsuccinyl-4')erythrane 
• 1255647-45-0 C₄₅H₅₈O₅ 
• 1255647-33-6 C₄₀H₅₆O₅ 
• 1255647-44-9 C₃₈H₅₂O₅ 
• 1255647-37-0 C₄₂H₆₀O₅ 
• 1255647-39-2 C₄₃H₆₂O₅ 
• 545-48-2 erythrodiol 

Relevant articles and documents

Synthesis and biological evaluation of oleanolic acid derivatives as antitumor agents

Derivatives of oleanolic acid were synthesized and evaluated in vitro for their growth inhibition against human hepatocellular carcinoma cell line (HepG2) and colon cancer cell line (Col-02). Several derivatives exhibited moderate-to-good inhibitory activity, with 3 displaying the most promising inhibition [GI50=1.75μM (HepG2), 0.71μM (Col-02)]. Structure-activity relationship analyses of these derivatives demonstrated that a 1-en-2-cyano-3-oxo in ring A and a nitro at C-17 were important in retention of the inhibition against HepG2 and Col-02 cells.

COMPOSITIONS COMPRISING TRITERPENOIDS AND USES THEREOF FOR TREATING OPTIC NEUROPATHY

The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating optic neuropathy conditions.

Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator in the process of insulin signaling and a promising drug target for diabetes and obesity. Derivatives of oleanolic acid were synthesized and evaluated as PTP1B inhibitors. Several derivatives exhibited moderate to good inhibitory activities against PTP1B, with 25f displaying the most promising inhibition (IC 50 = 3.12 μM). Structure-activity relationship analyses of these derivatives demonstrated that the integrity of the A ring and 12-ene moieties was important in the retention of PTP1B enzyme inhibitory activities. In addition, hydrophilic and acidic groups as well as the distance between the oleanene and acid moieties were associated with PTP1B inhibitory activities. Possible binding modes of 25f were explored by molecular docking simulations.