181058-08-2Relevant articles and documents
Self-Assembly of Spherical Organic Molecules to Form Hollow Vesicular Structures in Water for Encapsulation of an Anticancer Drug and Its Release
Sarkar, Koushik,Ahmed, Sabir,Dastidar, Parthasarathi
, p. 1992 - 1999 (2019)
Developing hierarchical supramolecular structures is important for better understanding of various biological functions and possibly generating new materials for biomedical applications. Herein, we report the first examples of functional vesicles derived from cationic spherical organic molecules (C1-C3) which were readily synthesized by reacting a C3-symmetric tris-benzimmidazole derivative (possessing a 1,3,5-ethyl substituted aromatic core) with 1,3,5-substituted tris-bromomethyl benzene derivatives. Vesicle formation by C1-C3 was probed by high-resolution microscopy (TEM and AFM), dynamic light scattering (DLS) and fluorescence microscopic imaging of calcein-loaded vesicles. One of the vesicles [Vesicle(C3)] displayed the ability to load the anticancer drug doxorubicin (DOX). The drug was subsequently released from DOX@Vesicle(C3) in a stimuli-responsive manner in presence of the well-known vesicle destroyer Triton X-100, as revealed by in vitro cell migration assay carried out on a highly aggressive human breast cancer cell line (MDA-MB-231).
From transient sulfenic acids toward peculiar sulfurated molecules
Barattucci, Anna,Bonaccorsi, Paola
, p. 199 - 203 (2017)
Sulfenic acids (R-SOH) frequently act as reactive intermediates in biological and synthetic chemistry. Among the numerous examples that Nature offers to our knowledge, cysteine-derived sulfenic acids are recognized as key intermediates in signal transduct
Supramolecular Alloys from Fluorinated Hybrid Tri4Di6 Imine Cages
Kunde, Tom,Pausch, Tobias,Schmidt, Bernd M.
, p. 8457 - 8460 (2021/05/24)
To create innovative materials, efficient control and engineering of pore sizes and their characteristics, crystallinity and stability is required. Eight hybrid Tri4Di6 imine cages with a tunable degree of fluorination and one fully fluorinated Tri4Di6 imine cage are investigated. Although the fluorinated and the non-fluorinated building blocks used herein differ vastly in reactivity, it was possible to gain control over the outcome of the self-assembly process, by carefully controlling the feed ratio. This represents the first hybrid material based on fluorinated/hydrogenated porous organic cages (POCs). These cages with unlimited miscibility in the solid state were obtained as highly crystalline samples after recrystallization and even showed retention of the crystal lattice, forming alloys. All mixtures and the fully fluorinated Tri4Di6 imine cage were analyzed by MALDI-MS, single-crystal XRD, powder XRD and in regard to thermal stability (TGA).
HEXASUBSTITUTED BENZENES, SURFACES MODIFIED THEREWITH, AND ASSOCIATED METHODS
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Paragraph 0028; 0154, (2021/03/19)
Phenyl rings provide a robust scaffold for molecular design, given the limited number of ring carbon atoms and the fixed geometry in between. However, it can be difficult to form highly substituted phenyl rings suitable for covalent attachment of multiple
Photo-thermal platinum nanoparticle with mannose targeting as well as preparation method and application thereof
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Paragraph 0028-0034, (2020/04/29)
The invention discloses a photo-thermal platinum nanoparticle with mannose targeting as well as a preparation method and application thereof. The photo-thermal platinum nanoparticle with mannose targeting is formed by self-assembling a polymer carrier, tw