18107-03-4Relevant articles and documents
Mono- and bi-nuclear ruthenium(II) complexes containing a new asymmetric ligand 3-(pyrazin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline: Synthesis, characterization and DNA-binding properties
Zou, Xiao-Hua,Ye, Bao-Hui,Li, Hong,Liu, Jin-Gang,Xiong, Ya,Ji, Liang-Nian
, p. 1423 - 1428 (1999)
A novel asymmetric ligand 3-(pyrazin-2-yl)-as-triazino[5,6-f]1,10-phenanthroline (pztp) and its mono- and bi-nuclear complexes [Ru(bpy)2(pztp)]2+ 1 and [(bpy)2Ru(pztp)Ru(bpy)2]4+ 2 (bpy = 2,2′-bipyridine) have been synthesized and characterized by UV/VIS, IR, 1H NMR and mass spectra. The electrochemical behaviours of complexes 1 and 2 were observed and displayed oxidation potentials at 1.37 and 1.39 and 1.60 V vs. saturated calomel electrode, respectively. The binding of the two complexes with calf thymus DNA has also been investigated by a spectrophotometric method and viscosity measurements. The results indicated that the two complexes interact with DNA in sharply different ways. The mononuclear complex 1 intercalates into DNA base pairs despite its small hypochromicity value, while the binuclear complex 2 binds to DNA via electrostatic interaction. The circular dichroism signals of the dialysates of the racemic complexes against calf thymus DNA are discussed.
ANTI-BACTERIAL COMPOUNDS
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Page/Page column 35, (2008/06/13)
Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).