181130-14-3

Basic information

• Product Name: 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI)
• Synonyms: 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI);5-Aminomethyl-2-cyanopyridine;2-Pyridinecarbonitrile, 5-(aminomethyl)-;5-(aMinoMethyl)-2-Pyridinecarbonitrile;5-(AMinoMethyl)picolinonitrile
• CAS NO: 181130-14-3
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.153
• Product Categories: PYRIDINE
• Mol File: 181130-14-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 325.2 °C at 760 mmHg
• Flash Point: 150.5 °C
• Appearance: /
• Density: 1.17
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI)(181130-14-3)
• EPA Substance Registry System: 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI)(181130-14-3)

Safety Data

• Hazardous Substances Data: 181130-14-3(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI) is a chemical compound with the molecular formula C7H7N3. It is also known by the name 5-Aminomethyl-2-cyanopyridine. 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI) is a derivative of pyridine and contains a nitrile group and an aminomethyl substituent. It is used in the synthesis of various pharmaceuticals and agrochemicals. Additionally, 2-Pyridinecarbonitrile,5-(aminomethyl)-(9CI) may also have potential applications in other chemical processes and industries. It is important to handle this compound with care and follow all safety guidelines due to its chemical properties and potential hazards.

InChI:InChI=1/C7H7N3/c8-3-6-1-2-7(4-9)10-5-6/h1-2,5H,3,8H2

Upstream product

• 58553-48-3 5-(hydroxymethyl)pyridine-2-carbonitrile 
• 26218-78-0 methyl 6-bromonicotinate 
• 89809-65-4 methyl 6-cyanopyridine-3-carboxylate 
• 308846-06-2 5-(bromomethyl)pyridine-2-carbonitrile 
• 1620-77-5 5-methylpicolinonitrile 
• 3510-66-5 2-Bromo-5-methylpyridine 

Downstream Products

• 1027428-59-6 (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (6-cyano-pyridin-3-ylmethyl)-amide 
• 302341-61-3 tert-bulyl N-[(6-cyanopyridin-3-yl)methyl]carbamate 
• 609345-79-1 5-(aminomethyl)pyridine-2-carboximidamide 
• 182291-43-6 tert-butyl {(tert-butoxycarbonyl)[(1R)-2-[(2S)-2-({[(6-cyano-3-pyridinyl)methyl]amino}carbonyl)-2,5-dihydro-1H-pyrrol-1-yl]-1-(cyclohexylmethyl)-2-oxoethyl]amino}acetate 
• 181130-15-4 Boc-D-phenylalanylproline (6-cyano-3-picolyl)amide 

Relevant articles and documents

Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue

Paired basic amino acid cleaving enzyme 4 (PACE4), a serine endoprotease of the proprotein convertases family, has been recognized as a promising target for prostate cancer. We previously reported a selective and potent peptide-based inhibitor for PACE4, named the multi-Leu peptide (Ac-LLLLRVKR-NH2 sequence), which was then modified into a more potent and stable compound named C23 with the following structure: Ac-dLeu-LLLRVK-Amba (Amba: 4-amidinobenzylamide). Despite improvements in both in vitro and in vivo profiles of C23, its selectivity for PACE4 over furin was significantly reduced. We examined other Arg-mimetics instead of Amba to regain the lost selectivity. Our results indicated that the replacement of Amba with 5-(aminomethyl)picolinimidamide increased affinity for PACE4 and restored selectivity. Our results also provide a better insight on how structural differences between S1 pockets of PACE4 and furin could be employed in the rational design of selective inhibitors.

Thrombin inhibitors, the preparation and use thereof

Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.