181179-41-9Relevant articles and documents
Aniline derivative having polyunsaturated fatty acid residue and use thereof
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, (2008/06/13)
An aniline derivative of the formula (1) STR1 wherein R1 is an eicosapentaenoyl or docosahexaenoyl; R2 and R3 are each independently an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; R4 is a hydrogen atom, an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; and A is a single bond, --C(=O)NH--(CH2)n --NH-- wherein n is 2 or 3, or a bivalent group of the following formula STR2 wherein m and p are each independently 0 or 1. The aniline derivative of the present invention has high inhibitory activity against and high selectivity for ACAT derived from macrophage and is useful as an agent for the prophylaxis and treatment of arteriosclerosis.