1813-84-9

Basic information

• Product Name: 1,1-Difluor-3-brom-3-phenyl-cyclobutan
• Synonyms: 1,1-Difluor-3-brom-3-phenyl-cyclobutan
• CAS NO: 1813-84-9
• Molecular Weight: 247.082
• Mol File: 1813-84-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-Difluor-3-brom-3-phenyl-cyclobutan(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Difluor-3-brom-3-phenyl-cyclobutan(1813-84-9)
• EPA Substance Registry System: 1,1-Difluor-3-brom-3-phenyl-cyclobutan(1813-84-9)

Safety Data

• Hazardous Substances Data: 1813-84-9(Hazardous Substances Data)

Upstream product

• 52784-31-3 3-Phenylcyclobutanone 
• 536-74-3 phenylacetylene 
• 1716-70-7 2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane 
• 340-01-2 4,4-dichloro-3,3-difluoro-1-phenyl-cyclobutene 
• 100-42-5 styrene 
• 533-65-3 1,1-difluoro-3-phenyl-cyclobutane 

Downstream Products

• 1959-45-1 3,3-difluoro-1-phenylcyclobutene 
• 38425-47-7 3-phenyl-2-cyclobuten-1-one 
• 52784-31-3 3-Phenylcyclobutanone 
• 90843-07-5 3-phenyl-2-cyclobuten-1-ol 

Relevant articles and documents

Copper-Catalyzed Ring-Opening Defluoroborylation of gem-Difluorinated Cyclobutenes: A General Route to Bifunctional 1,3-Dienes and Their Applications

The exploration of the reactivity of gem-difluorinated small-size rings has continuously drawn attention in recent years but is limited to three-membered carbocycles. Herein we report a copper-catalyzed reaction of gem-fluorinated cyclobutenes with bis(pinacolato)diboron (B2pin2). A sequence of defluoroborylation and a ring-opening process produces B,F-bifunctional 1,3-dienes in a stereoselective manner. The transformation together with the efficient downstream coupling of the boronate and the fluoride moieties collectively constitutes a modular route to highly functionalized and stereocontrolled 1,3-dienes.