18139-63-4Relevant articles and documents
METHOD FOR PRODUCING ARYLSILANE COMPOUND CONTAINING HALOSILANE COMPOUND AS RAW MATERIAL
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Paragraph 0059-0063, (2020/03/06)
PROBLEM TO BE SOLVED: To provide a method for producing an arylsilane compound with low production cost. SOLUTION: A method for producing an arylsilane compound includes a reaction step for the cross-coupling reaction of a halosilane compound represented by general formula (A-1), (A-2), or (A-3) and an arylboronic acid pinacol ester in the presence of a nickel catalyst, a Lewis acid catalyst, and an organic base (R independently represent an aromatic hydrocarbon group, a heteroaromatic ring group, or a C1-20 hydrocarbon group; X independently represent a halogeno group or a trifluoromethanesulfonyloxy group). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
Comparative study of new and known thienyl derivatives of ene-yne benzylamine as mammalian squalene epoxidase inhibitors
Gotteland,Junquero,Oms,Delhon,Halazy
, p. 333 - 342 (2007/10/03)
Analogs of the well-known squalene epoxidase inhibitor (SE) NB-598 (2) have been prepared and tested as cholesterol biosynthesis inhibitors in HepG2 cells. Among the compounds tested, the vinylthiophene analog 4 and the tertiary amide derivative of thiophene 8 emerged as potent human SE inhibitors and probably bind to the enzyme in a very similar manner as NB-598 (2). Surprisingly enough, compounds 4 and 8, contrary to NB-598, are poor inhibitors of rat SE, thus further demonstrating major differences between mammalian enzymes from different species.
REACTION OF ALLYL AND PROPARGYL CHLORIDES WITH HYDROSILANES
Lukevits, E.,Pudova, O. A.,Sturkovich, R. Ya.,Gaukhman, A. P.
, p. 1352 - 1354 (2007/10/02)
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