18144-52-0Relevant articles and documents
KPF6-Mediated Esterification and Amidation of Carboxylic Acids
Sonam, None,Shinde, Vikki N.,Kumar, Anil
, p. 2651 - 2661 (2022/02/07)
A novel KPF6-promoted green method has been developed for the synthesis of esters and amides. A wide range of carboxylic acids and alcohols or amines worked well under the developed reaction conditions, thus providing good to excellent (61-98%) yields of
Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues
Zhou, Xiang,Wang, Xiao-Bing,Wang, Tao,Kong, Ling-Yi
, p. 8011 - 8021 (2008/12/23)
Three series (series A-C) of coumarin analogues with phenylpiperazine functions as substitution were designed and synthesized for studying their potential for treating Alzheimer's (AD) disease. Their anticholinesterase activities were assayed according to Ellmann's method against freshly prepared acetylcholinesterase (AChE) from Electrophorus electricus using donepezil as the reference compound. Pharmacological study and preliminary structure-activity relationships showed that coumarins with substitution on positions 3 and/or 4 have parallel anti-AchE activities compared with the reference compound.