181484-89-9

Basic information

• Product Name: (S)-2-tert-Butoxycarbonylamino-3-{1-[(4-methoxy-phenyl)-diphenyl-methyl]-1H-imidazol-4-yl}-propionic acid methyl ester
• CAS NO: 181484-89-9
• Molecular Weight: 541.647
• Mol File: 181484-89-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-tert-Butoxycarbonylamino-3-{1-[(4-methoxy-phenyl)-diphenyl-methyl]-1H-imidazol-4-yl}-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-tert-Butoxycarbonylamino-3-{1-[(4-methoxy-phenyl)-diphenyl-methyl]-1H-imidazol-4-yl}-propionic acid methyl ester(181484-89-9)
• EPA Substance Registry System: (S)-2-tert-Butoxycarbonylamino-3-{1-[(4-methoxy-phenyl)-diphenyl-methyl]-1H-imidazol-4-yl}-propionic acid methyl ester(181484-89-9)

Safety Data

• Hazardous Substances Data: 181484-89-9(Hazardous Substances Data)

Upstream product

• 20898-43-5 4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester 
• 71-00-1 L-histidine 
• 1499-46-3 L-Histidine methyl ester 

Downstream Products

• 1226852-38-5 tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate 

Relevant articles and documents

Synthesis of potent inhibitors of histidinol dehydrogenase

Novel inhibitors of histidinol dehydrogenase are described. The most potent inhibitors, compounds 18 (K(i)* = 4.4 nM) and 19 (K(i)* = 2.9 nM) exploit a hitherto unreported lipophilic binding pocket adjoining the active site. Preliminary SAR data for this pocket are detailed. The electrophilic ketone 6 designed to bind to an active site nucleophile was a considerably weaker inhibitor (IC50 ~ 20 μM).