181512-64-1

Basic information

• Product Name: 2-Pyridinecarboxamide, 1,6-dihydro-N-(4-methoxyphenyl)-6-oxo-1-(2-propynyl)-
• CAS NO: 181512-64-1
• Molecular Formula: C16H14N2O3
• Molecular Weight: 282.299
• Mol File: 181512-64-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxamide, 1,6-dihydro-N-(4-methoxyphenyl)-6-oxo-1-(2-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, 1,6-dihydro-N-(4-methoxyphenyl)-6-oxo-1-(2-propynyl)-(181512-64-1)
• EPA Substance Registry System: 2-Pyridinecarboxamide, 1,6-dihydro-N-(4-methoxyphenyl)-6-oxo-1-(2-propynyl)-(181512-64-1)

Safety Data

• Hazardous Substances Data: 181512-64-1(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 173442-36-9 methyl 6-oxo-1-(prop-2-yn-1-yl)-1,6-dihydropyridine-2-carboxylate 
• 30062-34-1 methyl 6-oxo-1,6-dihydropyridine-2-carboxylate 
• 19621-92-2 6-Hydroxypicolinic acid 
• 939055-78-4 6-oxo-1-(prop-2-yn-1-yl)-1,6-dihydropyridine-2-carboxylic acid 

Relevant articles and documents

Highly efficient and mild cascade reactions triggered by bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate and a concise total synthesis of camptothecin

A mild and efficient cascade methodology is reported to construct variously substituted indolizino[1,2-b]quinolin-9(11H)-ones. Efficiently triggered by bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate under mild conditions, this cascade achieved significant enhancements in chemical yields. Utilizing this highly efficient domino reaction followed by a Sharpless dihydroxylation, an eight-step total synthesis of camptothecln was accomplished from a known pyridine derivative in direct fashion with an overall yield of 47% and 95% ee.