18181-08-3 Usage
Description
α-Methyl-3,4-dihydroxy-L-phenylalanine methyl ester, also known as L-α-Methyl DOPA Methyl Ester, is a synthetic compound derived from the amino acid L-DOPA. It is characterized by the presence of a methyl group at the α-carbon and an ester group at the carboxy terminus. α-Methyl-3,4-dihydroxy-L-phenylalanine methyl ester is structurally similar to L-DOPA, a precursor of dopamine, and has potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
α-Methyl-3,4-dihyperoxy-L-phenylalanine methyl ester is used as an intermediate in the synthesis of L-α-Methyl DOPA Methyl Ester Hydrochloride, which is a Methyldopa angiotensin II analog. Methyldopa is a centrally acting antihypertensive drug that works by converting to α-methylnorepinephrine, which stimulates central α2-adrenergic receptors, leading to a decrease in blood pressure.
Additionally, due to its structural similarity to L-DOPA, α-Methyl-3,4-dihydroxy-L-phenylalanine methyl ester may have potential applications in the treatment of Parkinson's disease, as L-DOPA is a precursor to dopamine and is used to replenish dopamine levels in the brain.
However, it is important to note that α-Methyl-3,4-dihydroxy-L-phenylalanine methyl ester is an impurity in the synthesis of L-α-Methyl DOPA Methyl Ester Hydrochloride, and further research and development are needed to explore its potential applications and optimize its synthesis process.
Check Digit Verification of cas no
The CAS Registry Mumber 18181-08-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,8 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18181-08:
(7*1)+(6*8)+(5*1)+(4*8)+(3*1)+(2*0)+(1*8)=103
103 % 10 = 3
So 18181-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO4/c1-11(12,10(15)16-2)6-7-3-4-8(13)9(14)5-7/h3-5,13-14H,6,12H2,1-2H3/t11-/m0/s1
18181-08-3Relevant articles and documents
Preparation process of L-methyldopa methyl ester
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Paragraph 0032; 0034; 0035; 0036, (2018/07/15)
The invention relates to a preparation process of L-methyldopa methyl ester and belongs to the field of organic chemical synthesis. The preparation process of the L-methyldopa methyl ester comprises the following steps of 1, sequentially adding L-methyldo
