18189-21-4

Basic information

• Product Name: 1-(4-formylphenyl)-2-phenylethane-1,2-dione
• Synonyms: 1-(4-formylphenyl)-2-phenylethane-1,2-dione
• CAS NO: 18189-21-4
• Molecular Weight: 238.243
• Mol File: 18189-21-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-(4-formylphenyl)-2-phenylethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-formylphenyl)-2-phenylethane-1,2-dione(18189-21-4)
• EPA Substance Registry System: 1-(4-formylphenyl)-2-phenylethane-1,2-dione(18189-21-4)

Safety Data

• Hazardous Substances Data: 18189-21-4(Hazardous Substances Data)

Upstream product

• 2431-00-7 p-methylbenzil 
• 18189-19-0 (4-(Bromomethyl)phenyl)phenylethanedione 
• 32555-96-7 4-styrylbenzaldehyde 
• 536-74-3 phenylacetylene 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 87199-17-5 4-formylphenylboronic acid, 
• 637-44-5 phenylpropyolic acid 
• 57341-98-7 4-(phenylethynyl)benzaldehyde 
• 18189-20-3 C-<4-Phenylglyoxyloylphenyl>-N-<4-dimethylamino-phenyl>-nitron 

Downstream Products

• 21514-65-8 4,4'-Bis-(4-benzoylcarbonyl-styryl)-benzil 
• 18189-29-2 all-trans-1,6-Bis-(4-phenyl-glyoxyloyl-phenyl)-hexatrien-(1,3,5) 
• 18189-25-8 trans-1,2-Bis-(4-phenyl-glyoxyloyl-phenyl)-ethen 

Relevant articles and documents

Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C?H Halogenation

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and dimethyl sulfoxide (DMSO) for C?H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur

Catalyst-Free and Transition-Metal-Free Approach to 1,2-Diketones via Aerobic Alkyne Oxidation

A catalyst-free and transition-metal-free method for the synthesis of 1,2-diketones from aerobic alkyne oxidation was reported. The oxidation of various internal alkynes, especially more challenging aryl-alkyl acetylenes, proceeded smoothly with inexpensive, easily handled, and commercially available potassium persulfate and an ambient air balloon, achieving the corresponding 1,2-diketones with up to 85% yields. Meanwhile, mechanistic studies indicated a radical process, and the two oxygen atoms in the 1,2-diketons were most likely from persulfate salts and molecular oxygen, respectively, rather than water.

Sequentially Pd/Cu-Catalyzed Alkynylation-Oxidation Synthesis of 1,2-Diketones and Consecutive One-Pot Generation of Quinoxalines

We report a simple and efficient one-pot synthesis of 1,2-diketones by concatenation of two Pd/Cu-catalyzed processes: Pd0/CuI-catalyzed Sonogashira coupling of terminal alkynes with aryl (pseudo)halides furnishes internal alkynes, which are directly transformed by PdII/CuII-catalyzed Wacker-type oxidation with DMSO and oxygen as dual oxidants to furnish 1,2-diketones. With this efficient, catalyst economical process, various aryl iodides and triflates are efficiently transformed in high yields into symmetrically and unsymmetrically substituted 1,2-diketones with various functional groups. This process can be readily extended to a consecutive one-pot synthesis of quinoxalines in a diversity-oriented fashion.