18190-44-8Relevant articles and documents
Extending the chemical product tree: A novel value chain for the production of: N -vinyl-2-pyrrolidones from biogenic acids
Haus, Moritz Otto,Louven, Yannik,Palkovits, Regina
, p. 6268 - 6276 (2019)
The sustainable production of polymers from biogenic platform chemicals shows great promise to reduce the chemical industry's dependence on fossil resources. In this context, we propose a new two-step process leading from dicarboxylic acids, such as succinic and itaconic acid, to N-vinyl-2-pyrrolidone monomers. Firstly, the biogenic acid is reacted with ethanolamine and hydrogen using small amounts of water as solvent together with solid catalysts. For effective conversion, the optimal catalyst (carbon supported ruthenium) has to hold the ability of activating H2 as well as (imide) CO bonds. The obtained products, N-(2-hydroxyethyl)-2-pyrrolidones, are subsequently converted in a continuous gas phase dehydration over simple sodium-doped silica, with excellent selectivity of above 96 mol% and water as the sole by-product. With a final product yield of ≥72 mol% over two process steps and very little waste due to the use of heterogeneous catalysis, the proposed route appears promising-commercially as well as in terms of Green Chemistry.
A procedure for preparing N-hydroxyethyl-substituted succinimide and phthalimide
Gasanov,Allakhverdiev
, p. 2034 - 2035 (2004)
Conditions of synthesis of N-hydroxyethyl-substituted succinimide and phthalimide by reactions of dicarboxylic acid imides with aminoethanol were optimized.
IMPROVED PROCESS FOR THE PREPARATION OF DIROXIMEL FUMARATE AND SOLID FORMS THEREOF
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Page/Page column 22; 23, (2021/04/23)
Aspects of the present application relate to crystalline and amorphous solid forms of Diroximel fumarate, pharmaceutical compositions and processes thereof. Further, aspects relate to improved processes for the preparation of Diroximel fumarate and interm
Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide
Guo, Jian,Li, Wenming,Xue, Weiwei,Ye, Xin-Shan
supporting information, p. 2135 - 2141 (2017/03/17)
In the new transition-state based sialyltransferase inhibitors, an amide group was placed at the corresponding C-2 position of CMP-sialic acid to mimic the geometry and charge distribution in the transition state, and simple aromatic or aliphatic rings were used instead of the sialic acid moiety. All synthetic compounds exhibited excellent α(2-6)-sialyltransferase inhibition, resulting in up to a 2600-fold higher affinity for the enzyme than CMP-Neu5Ac, suggesting that amide is a key element for simulating transition-state features.