18212-21-0

Basic information

• Product Name: 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid
• Synonyms: 4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID;4-METHYL-1,2,3-THIODIAZOLE-5-CARBOXYLIC ACID;LABOTEST-BB LT00453848;BUTTPARK 30\06-41;IFLAB-BB F2630-0005;OTAVA-BB BB7020410078;TIMTEC-BB SBB005418;4-Methyl-1,2,3-Thiadiazole-5-C
• CAS NO: 18212-21-0
• Molecular Formula: C₄H₄N₂O₂S
• Molecular Weight: 144.15
• Product Categories: Nitrogen cyclic compounds;Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Building BlocksBuilding Blocks;New Products for Chemical Synthesis;Thiadiazoles
• Mol File: 18212-21-0.mol
• Article Data: 23

Chemical Properties

• Melting Point: 166 °C
• Boiling Point: 315.173 °C at 760 mmHg
• Flash Point: 144.412 °C
• Appearance: white to light yellow crystal powder
• Density: 1.531 g/cm³
• Vapor Pressure: 0.000188mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Aqueous Base (Slightly), DMSO
• PKA: 1.33±0.37(Predicted)
• CAS DataBase Reference: 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid(18212-21-0)
• EPA Substance Registry System: 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid(18212-21-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 18212-21-0(Hazardous Substances Data)

Usage

Description

4-Methyl-1,2,3-thiadiazole-5-carboxylic acid is an organic compound characterized by a white to light yellow crystalline powder. It features a unique chemical structure that includes a thiadiazole ring with a methyl group and a carboxylic acid functional group, which contributes to its diverse range of applications.

Uses

Used in Agrochemical Industry:
4-Methyl-1,2,3-thiadiazole-5-carboxylic acid is used as an active ingredient in agrochemicals for its antiviral, fungicidal, and insecticidal properties. Its ability to combat various pathogens and pests helps protect crops and improve agricultural yields.
In the Agrochemical Industry, 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid is used as an antiviral agent to protect plants from viral infections, ensuring healthier growth and higher crop quality.
4-Methyl-1,2,3-thiadiazole-5-carboxylic acid is also used as a fungicide, effectively controlling fungal infections that can damage crops and reduce yields.
Additionally, 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid is used as an insecticide, targeting pests that threaten the productivity and quality of crops.

InChI:InChI=1/C4H4N2O2S/c1-2-3(4(7)8)9-6-5-2/h1H3,(H,7,8)/p-1

Upstream product

• 1260230-38-3 4-butyl-1-(4-methyl-1,2,3-thiadiazol-5-yl-carbonyl)-thiosemicarbazide 
• 1260230-39-4 4-ethyl-1-(4-methyl-1,2,3-thiadiazol-5-yl-carbonyl)-thiosemicarbazide 
• 175136-67-1 4-methyl-1,2,3-thiadiazole-5-carboxylic acid-(N-benzoyl-N-cyclohexyl)-amide 
• 59944-65-9 4-methyl-[1,2,3]thiadiazole-5-carbonyl chloride 
• 1047997-69-2 N'-tert-butyl-3-methoxybenzohydrazide 
• 183298-93-3 methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate 
• 18212-20-9 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester 

Downstream Products

• 59944-66-0 (4-methyl-1,2,3-thiadiazol-5-yl)(phenyl)methanone 
• 637336-42-6 4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid {4-[3-cyclopropylmethyl-1-(2-fluorobenzyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-methyl-amide 
• 1193530-97-0 isosorbide-2-aspirinate-5-(4-methyl-1,2,3-thiadiazole-5-oate) 
• 175136-67-1 4-methyl-1,2,3-thiadiazole-5-carboxylic acid-(N-benzoyl-N-cyclohexyl)-amide 

Relevant articles and documents

Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB

N-(5-Chlorobenzo[d]oxazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-carboxamideox-amide has been identified as a potent inhibitor of Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 0.42 μM. In this study, a series of substituted 2-acylamide-1,3-zole analogues were designed and synthesized, and their anti-Mtb activities were analyzed. In total, 17 compounds were found to be potent anti-Mtb agents, especially against the MDR- and XDR-MTB strains, with MIC values 10 μM. These analogues can inhibit both drug-sensitive and drug-resistant Mtb. Four representative compounds were selected for further profiling, and the results indicate that compound 18 is acceptably safe and has favorable pharmacokinetic (PK) properties. In addition, this compound displays potent activity against Gram-positive bacteria, with MIC values in the range of 1.48–11.86 μM. The data obtained herein suggest that promising anti-Mtb candidates may be developed via structural modification, and that further research is needed to explore other compounds.

Substituted benzo - 1, 3 - [...] compound, its preparation and use

The invention relates to a substituted benzo-1, 3-miscellaneous azole compound shown in the general formula I, and further relates to a preparation method of the compound and application to the preparation of antituberculosis drugs. The compound provided by the invention has effect not only on mycobacterium tuberculosis sensitive strains, but also on resistant strains which have drug resistance to isoniazid, rifampicin, and other traditional frontline antituberculosis drugs, and is a novel antimycobacterium tuberculosis compound.

guan Huanfa synthetic multi-nitrogen heterocyclic ring sai oxadiazole - 5 - a amidine compounds

The invention discloses an N-trisubstituted-1,2,3-thiadiazoles-5-formamidine target compound of which the general formula is TDCA. The N-trisubstituted-1,2,3-thiadiazoles-5-formamidine target compound is obtained from an M compound through a cyclization reaction. The new synthetizing method is high in yield, catalysts are easy to prepare, the catalysts are low in cost, phosphoric waste water is less, and the multi-nitrogen heterocycle thiadiazoles-5-formamidine compound is environment-friendly. (As shown in the Description).