182210-51-1

Basic information

• Product Name: cis-(1R,2S)-1,2-epoxy-1-phenyl-3-butene
• Synonyms: cis-(1R,2S)-1,2-epoxy-1-phenyl-3-butene
• CAS NO: 182210-51-1
• Molecular Weight: 146.189
• Mol File: 182210-51-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: cis-(1R,2S)-1,2-epoxy-1-phenyl-3-butene(CAS DataBase Reference)
• NIST Chemistry Reference: cis-(1R,2S)-1,2-epoxy-1-phenyl-3-butene(182210-51-1)
• EPA Substance Registry System: cis-(1R,2S)-1,2-epoxy-1-phenyl-3-butene(182210-51-1)

Safety Data

• Hazardous Substances Data: 182210-51-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 106-95-6 allyl bromide 
• 182210-43-1 syn-(1R,2R)-2-chloro-1-phenyl-3-buten-1-ol 
• 107-05-1 3-chloroprop-1-ene 
• 88086-64-0 (1S,2S)-2-Chloro-1-phenyl-but-3-en-1-ol 
• 341525-05-1 2-Bromo-1-phenyl-but-3-en-1-ol 

Relevant articles and documents

New access to chiral syn-α-Chlorohydrins and cis-vinyloxiranes through chloroallyboration

A new method to generate chiral cis-vinyloxiranes from readily available starting materials is reported. (X-Chloroallyl)lithium, generated in situ from LiN(c-Hex)2 and allyl chloride at -95°C, reacts with (-)-β-methoxydiisopinocampheylborane,

Sulfur-ylide-mediated synthesis of functionalized and trisubstituted epoxides with high enantioselectivity; Application to the synthesis of CDP-840

Benzyl and substituted allyl sulfonium salts react with a broad range of simple and functionalized aldehydes and ketones to give epoxides with high diastereoselectivity and high enantioselectivity (see scheme). The process has been applied to a short synthesis of the phosphodiesterase-IV inhibitor CDP-840. R1, R2 = hydrogen, alkyl, alkenyl, alkynyl, aryl, or pyridyl.