182211-07-0

Basic information

• Product Name: (1S,2S)-N-cyanomethyl-pseudoephedrine
• Synonyms: (1S,2S)-N-cyanomethyl-pseudoephedrine
• CAS NO: 182211-07-0
• Molecular Weight: 204.272
• Mol File: 182211-07-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,2S)-N-cyanomethyl-pseudoephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-N-cyanomethyl-pseudoephedrine(182211-07-0)
• EPA Substance Registry System: (1S,2S)-N-cyanomethyl-pseudoephedrine(182211-07-0)

Safety Data

• Hazardous Substances Data: 182211-07-0(Hazardous Substances Data)

Upstream product

• 90-82-4 pseudoephedrine 
• 590-17-0 cyanomethyl bromide 
• 107-16-4 glycolonitrile 

Downstream Products

• 452096-19-4 pseudoephedrine-derived chloride 
• 206256-43-1 (5S,6S)-4,5-dimethyl-6-phenyl-2-morpholone 
• 452096-27-4 (2R,3R,4S)-1,4-dimethyl-3-phenyl-azetidine-2-carbonitrile 
• 452096-26-3 (2S,3R,4S)-1,4-dimethyl-3-phenyl-azetidine-2-carbonitrile 

Relevant articles and documents

A straightforward synthesis of enantiopure 2-cyano azetidines from β-amino alcohols

Enantiopure 2-cyano azetidines were prepared in high yields from β-amino alcohols. This synthesis was shown to be general and is based on two important steps: (i) chlorination of a N-cyanomethylated β-amino alcohol and (ii) a 4-exo-trig ring closure through the alkylation of a lithiated α-amino nitrile. The former step is stereoselective when ephedrine-derived β-amino alcohols are used. In the case of a phenylglycinol-derived β-amino alcohol, this step also involves a rearrangement.