182344-13-4

Basic information

• Product Name: 3-Chloro-4-hydroxyphenylboronic acid
• Synonyms: 3-Chloro-4-hydroxybenzeneboronicacid96%;3-Chloro-4-hydroxyphenylboronic Acid (contains varying amounts of Anhydride);(3-Chloro-4-hydroxyphenyl);B-(3-chloro-4-hydroxy-phenyl)boronic acid;3-Chloro-4-hydroxyphenylboronic acid;3-Chloro-4-hydroxybenzeneboronic acid;4-Borono-2-chlorophenol
• CAS NO: 182344-13-4
• Molecular Formula: C₆H₆BClO₃
• Molecular Weight: 172.37
• Product Categories: blocks;BoronicAcids;Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 182344-13-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 223-228°C
• Boiling Point: 360.6 °C at 760 mmHg
• Flash Point: 171.9 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 7.91E-06mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 3-Chloro-4-hydroxyphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-hydroxyphenylboronic acid(182344-13-4)
• EPA Substance Registry System: 3-Chloro-4-hydroxyphenylboronic acid(182344-13-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT, KEEP COLD
• Hazardous Substances Data: 182344-13-4(Hazardous Substances Data)

Usage

Uses

suzuki reaction

InChI:InChI=1/C6H6BClO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9-11H

Upstream product

• 3964-56-5 4-bromo-2-chlorophenol 

Downstream Products

• 1357563-67-7 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone 
• 1357564-23-8 [6-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-(3-methoxyphenyl)-methanone 
• 1357563-52-0 [6-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-(3-hydroxyphenyl)-methanone 
• 1357563-77-9 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(4-fluoro-3-methoxyphenyl)-methanone 
• 1357563-38-2 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(4-fluoro-3-hydroxyphenyl)-methanone 
• 1357564-05-6 (4-fluoro-3-methoxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone 
• 1357563-44-0 (4-fluoro-3-hydroxyphenyl)-[5-(3-chloro-4-hydroxyphenyl)-pyridin-2-yl]-methanone 
• 1621363-14-1 2-(4-(2-(3-chloro-4-hydroxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methyl ester 

Relevant articles and documents

COMPOUND

There is provided a compound of Formula (I):wherein R3, R4, R5, R6, R7, R9, and R10, are independently selected from -H, -OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (-CN), nitro (-NO2 ), and halogens; wherein ring A is optionally further substituted wherein X is a bond or a linker group wherein (A) (i) R9 is selected from alkyl and halogen groups; and (ii) R10 is selected from -OH, oxyhydrocarbyl and -OSO 2 NR1 R2 ; wherein R1 and R2 are independently selected from H and hydrocarbyl or (B) at least one of R3 , R4 , R5 , R6 and R7 is the group -C(=0)-CR11 R12 -R8 wherein R8 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkylheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group or alkenyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is -CH 2 - or - CH 2 CH 2 -, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of alkylheterocycle group, alkenylheterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi)-CHO, or together with another of R3 , R4 , R5 , R6 and R7 the enol tautomer thereof wherein R11 and R12 are independently selected from H and hydrocarbyl; or (C) at least one of R3 , R4 , R5 , R6 and R7 together with another of R3 , R4 , R5 , R6 and R7 forms a ring containing -C(=O)-; or (D) at least one of R3 , R4 , R5 , R6 and R7 is selected from alkylheterocycle group, alkenylheterocycle group, alkylheteroaryl group, alkenylheteroaryl group, and heteroaryl groups or (E) at least one of R3 , R4 , R5 , R6 and R7 is selected from -CN, -C(R13 )=N-O-alkyl group, - C(R14 )=N-O-H group, optionally substituted pyrazole, optionally substituted thiazole, optionally substituted oxazole, optionally substituted isoxazole, optionally substituted pyridine, and optionally substituted pyrimidine, or together with another of R3 , R4 , R5 , R6 and R7 forms a nitrogen containing ring; wherein R13 and R14 are independently selected from H and hydrocarbyl

Biomarkers for phenol carcinogen exposure act as pH-sensing fluorescent probes

Biomarkers for phenolic carcinogen exposure, 8-(4″)-hydroxyphenyl)-2′-deoxypurines, have been found to possess pH-sensitive fluorescent properties. Phenolic ionization constants (pKa) establish substituent (σ-) constants of 0.46 for