182499-90-7

Basic information

• Product Name: Phenol, 2-amino-5-ethyl- (9CI)
• Synonyms: Phenol, 2-amino-5-ethyl- (9CI);4-amino-3-hydroxy(ethyl)benzene
• CAS NO: 182499-90-7
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• Product Categories: ALCOHOL
• Mol File: 182499-90-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 254.829 °C at 760 mmHg
• Flash Point: 107.917 °C
• Appearance: /
• Density: 1.116 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Phenol, 2-amino-5-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-amino-5-ethyl- (9CI)(182499-90-7)
• EPA Substance Registry System: Phenol, 2-amino-5-ethyl- (9CI)(182499-90-7)

Safety Data

• Hazardous Substances Data: 182499-90-7(Hazardous Substances Data)

Usage

General Description

Phenol, 2-amino-5-ethyl- (9CI) is a chemical compound with the molecular formula C8H11NO. It is also known by its systematic name 2-amino-5-ethylphenol. Phenol, 2-amino-5-ethyl- (9CI) is a derivative of phenol, a common organic compound. It contains an amino group and an ethyl group attached to the aromatic ring. It is commonly used in the production of dyes, as well as in the synthesis of pharmaceuticals and other organic compounds. This chemical may also have potential applications in the field of medicine and biochemistry, but further research is needed to fully understand its properties and uses.

Upstream product

• 620-17-7 3-ethylphenol 
• 179542-88-2 N-(4-ethyl-2-hydroxy-phenyl)-acetamide 
• 101664-28-2 5-ethyl-2-nitrophenol 

Downstream Products

• 182499-15-6 N-[2-Hydroxy-4-ethylphenyl]-N'-[2-bromophenyl] urea 

Relevant articles and documents

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

In order to elucidate the chemical structure of black to brown pigments, neuromelanins (NMs), in the substantia nigra (SN) and the locus coeruleus (LC) in the central nervous system of humans and other mammalian species during aging, chemical degradative methods are powerful tools. HPLC analysis after hydroiodic acid hydrolysis detected aminohydroxyphenylethylamines, aminohydroxyphenylacetic acids, and aminohydroxyethylbenzenes, which confirmed that SN-NM and LC-NM contain melanin derived not only from dopamine and norepinephrine (NE) but also from several other catecholic metabolites, such as 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxymandelic acid, 3,4-dihydroxyphenylethanol, and 3,4-dihydroxyphenylethylene glycol, in addition to the corresponding Cys-derivatives in varying degrees. However, hydroiodic acid hydrolysis showed that LC-NM produced the same degradation products as were detected in SN-NM. Thus, we needed to develop a new chemical detection method to validate the existence of NE in LC-NM. In the present study, we report that HCl hydrolysis of LC-NM in the presence of thioglycolic acid yields new products arising from substitution of the hydroxyl group by thioglycolic acid at the benzyl position of NE and cysteinyl-NE. This is the first chemical evidence showing that NE and cysteinyl-NE are incorporated into LC-NM.

COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR

Compounds active as inhibitors of renin are described, as well as methods of using such compounds to treat diseases and conditions associated with the renin-angiotensin system. Formula (I)

IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: STR1 wherein interalia, X is oxygen or sulfur;Rb is NR 6 R. sub.7, alkcyl, aryl, arylC 1-4 alkyl, aryl C 2-4 alkenyl, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC 2-4 alkenyl, heterocyclic or heterocyclic C 1-4 alkyl, or a heterocyclic C 2-4 alkenyl moiety, camphor, all of which may be optionally substituted; R 1 is independently selected from hydrogen; halogen; nitro; cyano; C 1-10 alkyl; halosubstituted C 1-10 alkyl; C 2-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR. sub.8 R 8)q S(O) t R 4 ; hydroxy; hydroxy substituted C 1-4 alkyl; aryl; aryl C 1-4 alkyl; aryl C 2-10 alkenyl; aryloxy; aryl C 1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C 2-10 alkenyl; heteroaryl C 1-4 alkyloxy; heterocyclic; heterocyclic C 1-4 alkyl; heterocyclicC 1-4 alkyloxy; heterocyclic C 2-10 alkenyl; q is 0 or an integer having a value of 1 to 10; n is an integer having a value of 1 to 3;m is an integer having a value of 1 to 3; Y is hydrogen; halogen; nitro; cyano; halosubstituted C 1-10 alkyl; C 1-10 alkyl; C 2-10 alkenyl C. sub.1-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR 8 R. sub.8)qS(O) t R 4, (CR 8 R 8)qOR 4 ; hydorxy; hydroxy substituted C. sub.1-4 alkyl; aryl; aryl C 1-4 alkyl; aryloxy; arylC. sub.1-4 alkyloxy; aryl C 2-10 alkenyl; heteroaryl; heteroarylalkyl; heteroaryl C 1-4 alkyloxy; heteroaryl C 2-10 alkenyl; heterocyclic, heterocyclic C 1-4 alkyl; heterocyclicC 2-10 alkenyl;or a pharmaceutically acceptable salt thereof.