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18251-36-0

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  • 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-20-ol,3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-,(4aS,16aS)-

    Cas No: 18251-36-0

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  • 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-20-ol,3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-,(4aS,16aS)- cas 1

    Cas No: 18251-36-0

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18251-36-0 Usage

Description

Thalidezine is an isoquinoline alkaloid belonging to the bisbenzylisoquinoline type, derived from Thalictrum fendleri Engelm. This alkaloid forms colorless crystals when extracted with Me2CO and exhibits an optical rotation of [α]25D + 236° (CHCl3). Its ultraviolet spectrum has a single absorption maximum at 283 mJ.1. The D-methyl ether of Thalidezine is identical to Hernandezine, while the D-ethyl ether forms colorless crystals with a melting point of 117-120°C.

Uses

Used in Pharmaceutical Industry:
Thalidezine is used as a therapeutic agent for the treatment of cancers and neurodegenerative diseases. Its unique chemical structure and properties make it a promising candidate for developing novel drugs to combat these conditions.

References

Shamma, Shine, Dudock., Tetrahedron, 23, 2887 (1967)

Check Digit Verification of cas no

The CAS Registry Mumber 18251-36-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,2,5 and 1 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18251-36:
(7*1)+(6*8)+(5*2)+(4*5)+(3*1)+(2*3)+(1*6)=100
100 % 10 = 0
So 18251-36-0 is a valid CAS Registry Number.

18251-36-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name THALIDEZINE

1.2 Other means of identification

Product number -
Other names O5-demethyl-hernandezine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18251-36-0 SDS

18251-36-0Downstream Products

18251-36-0Relevant articles and documents

Aromatic hydroxylation of some isoquinoline type alkaloids

Wiriyachitra,Cava

, p. 2274 - 2277 (1977)

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