1826-24-0Relevant articles and documents
4,5-Dihydro-imidazol-2-ylidene-linked palladium complexes as catalysts for the direct C-H bond arylation of azoles
?zdemir, ?smail,?zdemir, Nam?k,Kalo?lu, Murat
, (2022/01/11)
Recently, PEPPSI-type palladium-complexes bearing N-heterocyclic carbene (NHC) ligand have commonly been used as the effective catalysts in the direct arylation of heteroaromatic compounds. In most of previous studies catalyzed by such complexes, unsatura
Arylation of heterocyclic compounds by benzimidazole-based N-heterocyclic carbene-palladium(II) complexes
?ahin, Neslihan,Gürbüz, Nevin,Karab?y?k, Hande,Karab?y?k, Hasan,?zdemir, ?smail
, (2019/12/25)
Specific C–H bond can be activated for arylation using aryl halide without the aid of directing the group in the case of electron-rich heteroarenes. The ability to readily generate halo substituted arylated heteroarenes is important in organic chemistry s
Palladium-carbene catalyzed direct arylation of five-membered heteroaromatics
?zdemir, ?smail,?zdemir, Nam?k,Kalo?lu, Murat,Kalo?lu, Nazan,Y?ld?r?m, ?lkay
, (2020/01/08)
Due to the industrial importance of bi(hetero)arenes, the synthesis of these compounds by homogeneous Pd-catalyzed direct arylation is an important research topic in modern organic chemistry. In this study, PEPPSI-type, (PEPPSI = Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation), new Pd-catalysts with N-heterocyclic carbene ligand were synthesized, and they were used as catalysts in the synthesis of bi(hetero)arenes by direct arylation process. The structures of Pd-carbene complexes were elucidated by different spectroscopic and analytical techniques such as NMR, FT-IR and elemental analysis. The more detailed structural characterization of one of the complexes was determined by single-crystal X-ray diffraction study. Pd-carbene complexes were used as effective catalysts in the direct arylation of five-membered heteroaromatics such as thiophene, furan and thiazole derivatives with (hetero)aryl bromides for 1 h, in the presence of 1 mol% of catalyst loading, and successful results were obtained.
