182621-56-3

Basic information

• Product Name: N-Methyl-4-phenyl-4-piperidinamine
• Synonyms: n-methyl-4-phenyl-4-piperidinamine;N-methyl-4-phenylpiperidin-4-amine
• CAS NO: 182621-56-3
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Mol File: 182621-56-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 299.946°C at 760 mmHg
• Flash Point: 166.316°C
• Appearance: /
• Density: 1.024g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: N-Methyl-4-phenyl-4-piperidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-4-phenyl-4-piperidinamine(182621-56-3)
• EPA Substance Registry System: N-Methyl-4-phenyl-4-piperidinamine(182621-56-3)

Safety Data

• Hazardous Substances Data: 182621-56-3(Hazardous Substances Data)

Usage

Description

N-Methyl-4-phenyl-4-piperidinamine, also known as Nuciferine, is a chemical compound belonging to the alkaloid family and is a derivative of piperidine. It has potential applications in the pharmaceutical industry due to its diverse biological activities, including anti-inflammatory, anti-oxidant, and anti-cancer properties. Nuciferine is also being studied for its potential role in treating cardiovascular diseases and metabolic disorders such as diabetes and obesity.

Uses

Used in Pharmaceutical Industry:
Nuciferine is used as a pharmaceutical agent for its potential therapeutic effects in various medical conditions. Its anti-inflammatory, anti-oxidant, and anti-cancer properties make it a promising candidate for the development of new drugs.
Used in Anti-Inflammatory Applications:
Nuciferine is used as an anti-inflammatory agent, helping to reduce inflammation and alleviate pain in various conditions.
Used in Anti-Oxidant Applications:
Nuciferine is used as an anti-oxidant, protecting cells from oxidative stress and damage, which can contribute to the prevention and treatment of various diseases.
Used in Anti-Cancer Applications:
Nuciferine is used as an anti-cancer agent, exhibiting potential inhibitory effects on tumor growth and progression. It may also enhance the efficacy of conventional chemotherapeutic drugs in resistant cases.
Used in Cardiovascular Disease Treatment:
Nuciferine is used in the treatment of cardiovascular diseases, potentially improving heart health and reducing the risk of heart-related complications.
Used in Metabolic Disorder Treatment:
Nuciferine is used in the treatment of metabolic disorders such as diabetes and obesity, potentially helping to regulate blood sugar levels and promote weight loss.

InChI:InChI=1/C12H18N2/c1-13-12(7-9-14-10-8-12)11-5-3-2-4-6-11/h2-6,13-14H,7-10H2,1H3

Upstream product

• 181641-53-2 1-Benzyl-4-(formylamino)-4-phenylpiperidine 
• 172733-78-7 N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide 
• 181641-49-6 1-benzyl-4-phenylpiperidin-4-ylamine 
• 591-51-5 phenyllithium 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 172734-03-1 1-Benzyl-4-(methylamino)-4-phenylpiperidine 

Downstream Products

• 172734-92-8 osanetant 
• 172734-92-8 (S)-(N)-(1-(3-(1-benzoyl-3(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide 
• 182621-57-4 {3-(3,4-Dichloro-phenyl)-3-[3-(4-methylamino-4-phenyl-piperidin-1-yl)-propyl]-piperidin-1-yl}-phenyl-methanone 

Relevant articles and documents

Method for preparing 4-methylamino-4-phenylpiperidine

The invention relates to a process for preparing a 4-alkoxycarbonylamino-1-benzyl-4-phenylpiperidine of formula (I) via hydrolysis of 1-benzyl-4-cyano-4-phenylpiperidine (II) in acidic medium and treatment of the 1-benzyl-4-phenyl-4-piperidinecarboxamide (III) thus obtained with bromine in the presence of an alkali metal alkoxide. The invention also relates to a process for preparing 4-methylamino-4-phenylpiperidine from compound (II).