182866-65-5

Basic information

• Product Name: Butanoic acid, 2-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino] -3-oxo-, methyl ester
• CAS NO: 182866-65-5
• Molecular Formula: C18H24N2O6
• Molecular Weight: 364.398
• Mol File: 182866-65-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino] -3-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino] -3-oxo-, methyl ester(182866-65-5)
• EPA Substance Registry System: Butanoic acid, 2-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino] -3-oxo-, methyl ester(182866-65-5)

Safety Data

• Hazardous Substances Data: 182866-65-5(Hazardous Substances Data)

Upstream product

• 73708-95-9 methyl 3-oxo-2-oximinobutanoate 
• 105-45-3 acetoacetic acid methyl ester 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 41172-77-4 (±)-2-amino-3-oxo-butyric acid methyl ester hydrochloride 
• 119153-86-5 C₁₆H₂₁NO₆ 
• 41445-88-9 Z-Val-OCO₂ⁱBu 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 13139-28-1 (S)-N-benzyloxycarbonylvalinamide 

Downstream Products

• 790663-92-2 2-(1-benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-1H-imidazole-4-carboxylic acid methyl ester 
• 203782-28-9 [(S)-1-(4-Carbamoyl-5-methyl-oxazol-2-yl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 203782-30-3 2-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-oxo-butyric acid methyl ester 
• 303041-82-9 (1-{4-[2-(1H-indol-3-yl)-ethylcarbamoyl]-5-methyl-oxazol-2-yl}-2-methyl-propyl)-carbamic acid benzyl ester 
• 203782-26-7 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid 
• 790663-97-7 Boc-(S)-val-benzyl-imidazole-carboxylic acid 
• 790663-95-5 1-benzyl-2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-5-methyl-1H-imidazole-4-carboxylic acid methyl ester 
• 182866-73-5 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

Transmembrane H+/Cl- cotransport activity of bis(amido)imidazole receptors

A series of sickle-shaped bis(amido) imidazoles are synthesized for their ion transport studies. Proton-anion binding by the neutral and protonated form of receptors assessed by 1H-NMR titration experiments confirmed better chloride binding by the protonated form of a receptor compared to its neutral form. The transport experiments across unimolecular vesicles (by HPTS and lucigenin assays) confirmed the H+/Cl- symport process under the applied pH gradient conditions. The transporter also allows anion antiport as evident from the studies under symmetrical pH conditions. The ionophoric activity by the mobile carrier mechanism is proved by the U-tube experiment.

A C3-symmetric molecular scaffold for the construction of large receptors

A novel C3-symmetric scaffold has been efficiently synthesized exhibiting the property that variable receptor arms can be easily attached by simple alkylation reactions; the utility of the scaffold as a skeleton for large receptors has been exa

Synthesis of functionalised oxazoles and bis-oxazoles

A new method for the synthesis of oxazoles, and in particular chiral non-racemic oxazoles derived from amino acids, has been developed. Thus, rhodium(II) catalysed reaction of diazocarbonyl compounds 6 and 11 in the presence of amides 8 and 10 results in regioselective insertion of the carbenoid into the amide N-H bond with formation of the β-carbonyl amides 9 and 12. Cyclodehydration of amides 9 and 12 using triphenylphosphine-iodine-triethylamine gives functionalised oxazoles 7 and 13. The oxazoles 13c and 13f were converted into the bis-oxazoles 17a and 17b by a second rhodium(II) catalysed regioselective N-H insertion reaction on the amides 15, followed by cyclodehydration.