182923-55-3

Basic information

• Product Name: 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE
• Synonyms: 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE;2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-amine;1-phenyl-3-(trifluoroMethyl)-1H-pyrazol-5-aMine;2-Phenyl-5-(trifluoromethyl)pyrazol-3-amine
• CAS NO: 182923-55-3
• Molecular Formula: C₁₀H₈F₃N₃
• Molecular Weight: 227.19
• Mol File: 182923-55-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 101-102 °C(Solv: ethanol (64-17-5))
• Boiling Point: 323.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 0.39±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE(182923-55-3)
• EPA Substance Registry System: 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE(182923-55-3)

Safety Data

• Hazardous Substances Data: 182923-55-3(Hazardous Substances Data)

Usage

General Description

2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ylamine is a chemical compound with the molecular formula C11H8F3N3. It is a pyrazole derivative with a trifluoromethyl group attached to the phenyl ring. 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE has multiple applications in the fields of pharmaceuticals and agrochemicals, due to its potential as a building block for the synthesis of various biologically active molecules. Its unique structure and properties make it a valuable tool for medicinal chemistry research. Additionally, the trifluoromethyl group contributes to the compound's lipophilicity and bioactivity, making it a promising candidate for drug development and pesticide design. Overall, 2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ylamine is a versatile chemical with potential for various applications in the field of chemical synthesis and the development of new pharmaceutical and agricultural products.

Upstream product

• 1093253-92-9 5-amino-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 110234-68-9 3-cyano-1,1,1-trifluoroacetone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1093253-95-2 N-methyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine 
• 1093253-97-4 N⁵-methyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4,5-diamine 
• 1188909-35-4 phenyl (1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)carbamate 
• 1610051-04-1 1-(3-(2-methoxypyrimidin-5-yl)-4-methyl-1-phenyl-1H-pyrazol-5-yl)-3-(1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)urea 

Relevant articles and documents

PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION

Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.

KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.