183013-50-5Relevant articles and documents
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor γ agonists
Lin, Chia-Hui,Peng, Yi-Hui,Coumar, Mohane Selvaraj,Chittimalla, Santhosh Kumar,Liao, Chun-Chen,Lyn, Ping-Chiang,Huang, Chin-Chieh,Lien, Tzu-Wen,Lin, Wen-Hsing,Hsu, John T.-A.,Cheng, Jai-Hong,Chen, Xin,Wu, Jian-Sung,Chao, Yu-Sheng,Lee, Hwei-Jen,Juo, Chiun-Gung,Wu, Su-Ying,Hsieh, Hsing-Pang
supporting information; experimental part, p. 2618 - 2622 (2010/03/02)
Utilizing medicinal chemistry design strategies such as benzo splitting and ring expansion, we converted PPARα/γ dual agonist 1 to selective PPARα agonists 19 and 20. Compounds 19 and 20 were 2- to 4-fold better than rosiglitazone at PPARγ receptor, with
