18325-45-6

Basic information

• Product Name: 2-(trityloxy)ethanol
• Synonyms: 2-(Trityloxy)ethanol; Ethanol, 2-(triphenylmethoxy)-
• CAS NO: 18325-45-6
• Molecular Formula: C₂₁H₂₀O₂
• Molecular Weight: 304.3823
• Mol File: 18325-45-6.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 439.7°C at 760 mmHg
• Flash Point: 191.1°C
• Density: 1.128g/cm³
• Vapor Pressure: 1.65E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 2-(trityloxy)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trityloxy)ethanol(18325-45-6)
• EPA Substance Registry System: 2-(trityloxy)ethanol(18325-45-6)

Safety Data

• Hazardous Substances Data: 18325-45-6(Hazardous Substances Data)

Usage

General Description

2-(trityloxy)ethanol is a chemical compound with the molecular formula C24H22O2. It is a colorless to light yellow oily liquid that is commonly used as a solvent and as a chemical intermediate in organic synthesis. It is derived from trityl alcohol and ethylene oxide, and it is essential for the production of various pharmaceuticals, polymers, and other specialty chemicals. The trityl group in the molecule provides stability and protection to the hydroxyl group, making 2-(trityloxy)ethanol a versatile compound for various chemical reactions. It is also known for its strong antioxidant properties and is frequently used in the formulation of coatings, adhesives, and sealants. Overall, 2-(trityloxy)ethanol is a valuable chemical with a wide range of industrial applications.

Upstream product

• 68883-09-0 1,2-bis-trityloxy-ethane 
• 107-21-1 ethylene glycol 
• 110-86-1 pyridine 
• 76-84-6 triphenylmethyl alcohol 
• 76-83-5 trityl chloride 
• 112289-48-2 2-Acetamido-2-deoxy-6-O-trityl-D-glucose 
• 596-43-0 bromo-triphenyl-methane 
• 119248-80-5 ((2R,3R,4S)-1,3,4,5-tetrahydroxy-6-(trityloxy)hexan-2-yl)acetamide 

Downstream Products

• 618106-86-8 2-(trityloxy)ethyl 4,6-di-O-acetyl-2,3-di-O-benzoyl-α-D-mannopyranoside 
• 131029-42-0 (2-(triphenylmethoxy)ethoxy)acetic acid 
• 519-73-3 triphenylmethane 
• 1290036-09-7 C₄₆H₄₅NO₄ 
• 82777-73-9 2-(trityloxy)ethanol methanesulfonate 
• 74684-99-4 1-Trityloxy-propan-2-one 
• 71697-18-2 1,2-propyleneglycol-1-triphenylmethyl ether 
• 3292-82-8 α-trityloxyacetaldehyde 
• 1392278-21-5 (E)-4-methyl-5-(trityloxy)pent-3-en-2-one 
• 110596-07-1 methyl (2E)-3-methyl-6-triphenylmethyloxy-2-hexenoate 

Relevant articles and documents

Mesomorphism and glass formation of phthalocyanine metal complexes with bulky substituents

This paper deals with the synthesis of phthalocyanine complexes, containing four oligo(oxyethylene)-, oxybenzene-, esther of p-oxybenzoic acid or p-oxyazobenzene side chains terminated by a bulky trityl substituent. Their purity was established by column

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics

The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at Cα, such amide bond surrogates need a chiral moiety. Here the asymmetric synthesis of a set of 24 N-sulfinyl propargylamines is presented. The condensation of various aldehydes with Ellman's chiral sulfinamide provides chiral N-sulfinylimines, which were reacted with (trimethylsilyl)ethynyllithium to afford diastereomerically pure N-sulfinyl propargylamines. Diverse functional groups present in the propargylic position resemble the side chain present at the Cα of amino acids. Whereas propargylamines with (cyclo)alkyl substituents can be prepared in a direct manner, residues with polar functional groups require suitable protective groups. The presence of particular functional groups in the side chain in some cases leads to remarkable side reactions of the alkyne moiety. Thus, electron-withdrawing substituents in the Cα-position facilitate a base induced rearrangement to α,β-unsaturated imines, while azide-substituted propargylamines form triazoles under surprisingly mild conditions. A panel of propargylamines bearing fluoro or chloro substituents, polar functional groups, or basic and acidic functional groups is accessible for the use as precursors of peptidomimetics.

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