18328-11-5

Basic information

• Product Name: 4-PHENYLBUTANAL
• Synonyms: PHENETHYL ACETALDEHYDE;PHENYLBUTYRALDEHYDE(4-);4-PHENYLBUTANAL;4-PHENYLBUTYRALDEHYDE;Benzenebutanal;Benzenebutyraldehyde;γ-Phenylbutyraldehyde
• CAS NO: 18328-11-5
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• Mol File: 18328-11-5.mol
• Article Data: 208

Chemical Properties

• Melting Point: 45-48 °C
• Boiling Point: 243.3°Cat760mmHg
• Flash Point: 115.9°C
• Appearance: /
• Density: 0.971g/cm³
• Vapor Pressure: 0.0323mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-PHENYLBUTANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLBUTANAL(18328-11-5)
• EPA Substance Registry System: 4-PHENYLBUTANAL(18328-11-5)

Safety Data

• Hazardous Substances Data: 18328-11-5(Hazardous Substances Data)

Usage

Description

4-PHENYLBUTANAL, with the CAS number 18328-11-5, is an organic compound that serves as a valuable intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its aldehyde functional group and a phenyl group attached to a butyl chain, which contributes to its reactivity and potential applications in different industries.

Uses

Used in Pharmaceutical Industry:
4-PHENYLBUTANAL is used as a reactant for the synthesis of latanoprost, a medication specifically designed to treat increased pressure inside the eye. This application takes advantage of its reactivity in organocatalyzed [3+2]-cycloaddition reactions, which are crucial for the production of latanoprost.

Synthesis Reference(s)

Chemistry Letters, 21, p. 423, 1992Journal of the American Chemical Society, 108, p. 1325, 1986 DOI: 10.1021/ja00266a049Tetrahedron Letters, 34, p. 6505, 1993 DOI: 10.1016/0040-4039(93)88090-6

InChI:InChI=1/C10H12O/c11-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7,9H,4-5,8H2

Upstream product

• 34993-02-7 2-(R)-amino-5-phenylpentanoic acid 
• 861534-32-9 4,N,N'-triphenyl-butyramidine 
• 3360-41-6 4-phenyl-butan-1-ol 
• 13214-66-9 4-phenyl-1-butylamine 
• 4265-99-0 N-methyl-4-phenylbutylamine 
• 873-66-5 1-propenylbenzene 
• 201230-82-2 carbon monoxide 
• 1126-76-7 1,2-Epoxy-4-phenylbutane 
• 121033-27-0 4-Phenyl-2-(phenylthio)butanal 
• 16520-62-0 4-Phenyl-1-butyne 
• 300-57-2 allylbenzene 
• 72709-29-6 (+/-)-1,2-diphenylpyrrolidine 
• 1821-12-1 4-Phenylbutyric acid 
• 119-61-9 benzophenone 

Downstream Products

• 85629-18-1 4-phenyl-butyraldehyde dimethylacetal 
• 14213-84-4 2-phenylethylstyrene 
• 57334-45-9 N-Phenylbutyl-dl-amphetamine 
• 183129-90-0 (2-Amino-5-phenethyl-thiophen-3-yl)-(2-chloro-phenyl)-methanone 
• 173409-88-6 (E)-1,6-diphenyl-2-hexen-1-one 
• 336628-04-7 (2R,3R)-2,3-dihydroxy-2,3-O-isopropylidene-1,6-diphenyl-1-hexanone 

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