1833-42-7Relevant articles and documents
para-Selective Benzylation of Aryl Iodides by the in situ Preparation of ArIF2: a Hypervalent Iodine-Guided Electrophilic Substitution
Chaudhry, Azka,Hyatt, I. F. Dempsey,Im, Haram,Jones, Taro J.,Noorollah, Jennifer,Siddiqi, Fatima,Singh, Nirvanie,Spatola, Nicholas R.
supporting information, (2020/04/16)
Hypervalent iodine-guided electrophilic substitution (HIGES) was described previously for the para-selective benzylation of aryl-λ3-iodane diacetates. One drawback of the method was the synthesis and isolation of hypervalent iodine starting mat
Modular Functionalization of Arenes in a Triply Selective Sequence: Rapid C(sp2) and C(sp3) Coupling of C?Br, C?OTf, and C?Cl Bonds Enabled by a Single Palladium(I) Dimer
Keaveney, Sinead T.,Kundu, Gourab,Schoenebeck, Franziska
, p. 12573 - 12577 (2018/09/18)
Full control over multiple competing coupling sites would enable straightforward access to densely functionalized compound libraries. Historically, the site selection in Pd0-catalyzed functionalizations of poly(pseudo)halogenated arenes has been unpredictable, being dependent on the employed catalyst, the reaction conditions, and the substrate itself. Building on our previous report of C?Br-selective functionalization in the presence of C?OTf and C?Cl bonds, we herein complete the sequence and demonstrate the first general arylations and alkylations of C?OTf bonds (in I dimer. This allowed the realization of the first general and triply selective sequential C?C coupling (in 2D and 3D space) of C?Br followed by C?OTf and then C?Cl bonds.
α,n-didehydrotoluenes by photoactivation of (chlorobenzyl) trimethylsilanes: An alternative to enyne-allenes cyclization
Protti, Stefano,Ravelli, Davide,Mannucci, Barbara,Albini, Angelo,Fagnoni, Maurizio
supporting information; experimental part, p. 8577 - 8580 (2012/09/22)
Doubly radical: A novel entry to ?,n-didehydrotoluene (DHT) diradicals is disclosed and proceeds through the photochemical activation of (chlorobenzyl)trimethylsilanes with chloride loss and elimination of the SiMe3+ group (see scheme). The products formed in solution are indicative of the intermediacy of the three isomers of the ?,n-DHT