18354-57-9

Basic information

• Product Name: 1-(Thieno[2,3-b]pyridin-5-yl)ethanone
• Synonyms: 1-(Thieno[2,3-b]pyridin-5-yl)ethanone;acetaldehyde compound with thieno[2,3-b]pyridine (1:1)
• CAS NO: 18354-57-9
• Molecular Formula: C₉H₇NOS
• Molecular Weight: 177.22298
• Mol File: 18354-57-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 117 °C
• Boiling Point: 305.631 °C at 760 mmHg
• Flash Point: 138.641 °C
• Appearance: /
• Density: 1.286 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: 2-8°C
• PKA: 2.35±0.40(Predicted)
• CAS DataBase Reference: 1-(Thieno[2,3-b]pyridin-5-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Thieno[2,3-b]pyridin-5-yl)ethanone(18354-57-9)
• EPA Substance Registry System: 1-(Thieno[2,3-b]pyridin-5-yl)ethanone(18354-57-9)

Safety Data

• Hazardous Substances Data: 18354-57-9(Hazardous Substances Data)

Usage

General Description

1-(Thieno[2,3-b]pyridin-5-yl)ethanone is a chemical compound with the molecular formula C10H7NOS. It is a heterocyclic compound that contains a thieno[2,3-b]pyridine ring system and an ethanone functional group. 1-(Thieno[2,3-b]pyridin-5-yl)ethanone is used in the research and development of pharmaceuticals and agrochemicals, as well as in the production of organic synthesis intermediates. It has also been studied for its potential biological activities, including its anticonvulsant and sedative effects. The compound may have applications in the fields of medicinal chemistry, neuropharmacology, and organic chemistry.

InChI:InChI=1/C9H7NOS/c1-6(11)8-4-7-2-3-12-9(7)10-5-8/h2-5H,1H3

Upstream product

• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 151424-17-8 thiophene amine 
• 609-40-5 2-nitrothiophene 

Downstream Products

• 127019-40-3 3-bromo-5-acetylthieno<2,3-b>pyridine 
• 1400741-57-2 4-methyl-N'-(1-(thieno[2,3-b]pyridin-5-yl)ethylidene)benzenesulfonohydrazide 
• 21344-43-4 thieno[2,3-b]pyridin-5-yl-acetic acid methyl ester 
• 21344-30-9 thieno[2,3-b]pyridine-5-carboxylic acid methyl ester 
• 51043-52-8 N-(5-ethyl-thieno[2,3-b]pyridin-3-yl)-acetamide 
• 51043-51-7 5-ethyl-3-nitro-thieno[2,3-b]pyridine 
• 117390-42-8 N-methyl 5-carbamoyl thieno<2,3-b>pyridinium iodide 
• 117390-40-6 5-carbamoyl thieno<2,3-b>pyridine 
• 108460-24-8 6-carbamoyl 4,7-dihydro thieno<3,2-b>pyridine 
• 108460-23-7 5-carbamoyl 4,7-dihydro thieno<2,3-b>pyridine 
• 53566-62-4 1-(3-chloro-thieno[2,3-b]pyridin-5-yl)-ethanone 
• 21344-44-5 1-thieno[2,3-b]pyridin-5-yl-ethanone oxime 
• 117390-38-2 thieno<2,3-b>pyridine-5-carboxylic acid 
• 18354-54-6 5-ethylthieno<2,3-b>pyridine 

Relevant articles and documents

Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the N-tosylhydrazone.

SYNTHESIS, COMPLEXATION STUDY AND REACTIVITY OF ANNELATED THIOPHENIC NADH MODELS.

The synthesis of two carbamoyl 4,7-dihydrothienopyridines 1a and 1b is described.These derivatives are potential new NADH models.A NMR study of the complexation of magnesium ions by these compounds has been performed.The behaviour of the thieno derivative is different of that of thieno derivative: in the former the sulfur atom plays an impotant role in the complexation.The biomimetic reduction of p.nitrobenzaldehyde with 1a or 1b has been studied.The reactivity of the thiophenic annelated NADH models is very superior to that of quinoline analogous.It can be compared to the reactivity of common models such as N-benzyl 1,4-dihydronicotinamide (BNAH).Moreover 1a and 1b can be used in conditions were BNAH is much more less effective.