1837-91-8 Usage
Description
1,2,3,4,5,6-Hexabromocyclohexane is a chemical compound that is a potent and specific inhibitor of JAK2 autophosphorylation.
Uses
Used in Pharmaceutical Industry:
1,2,3,4,5,6-Hexabromocyclohexane is used as a pharmaceutical agent for its inhibitory effect on JAK2 autophosphorylation, which plays a crucial role in various cellular processes and diseases. Its ability to inhibit JAK2 autophosphorylation makes it a potential candidate for the development of drugs targeting conditions related to this pathway.
Biological Activity
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.
Check Digit Verification of cas no
The CAS Registry Mumber 1837-91-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,3 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1837-91:
(6*1)+(5*8)+(4*3)+(3*7)+(2*9)+(1*1)=98
98 % 10 = 8
So 1837-91-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
1837-91-8Relevant articles and documents
Photochemical Bromination of Anilides by Benzenehexabromide
Aly, M. M.,Awad, I. M. A.,Fahmy, A. M.
, p. 77 - 80 (2007/10/02)
Benzenehexabromide was found to afford photochemical bromination of substituted acetanilide in the p-position.The rates of bromination were found to follow the order predicted on the basis of inductive effect of the substituents and similar to the sequence of reactivities observed for bromination of acetanilides with N-bromosuccinimide.Similar results were obtained in the case of p-substituted benzanilides and the reaction shows a good Hammett correlation with the ?+ values for the substituents with a ρ value -0.266.
Bromination of Methyl Substituted 1,2,5-Thiadiazoles with N-Bromosuccinimide
Mataka, Shuntaro,Kurisu, Masayoshi,Takahashi, Kazufumi,Tashiro, Masashi
, p. 1157 - 1160 (2007/10/02)
Bromomethyl-1,2,5-thiadiazoles 2a-c were prepared by bromination of methyl-1,2,5-thiadiazoles 1a-c by NBS in refluxing carbon tetrachloride.When bromination of 1a and 1b was carried out under irradiation of tungsten lamp, mixtures of cis-5a and b and tran