18381-45-8 Usage
Description
3-Cyanopropionaldehyde Diethyl Acetal is a colorless oil that serves as a versatile chemical intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
3-Cyanopropionaldehyde Diethyl Acetal is used as a starting reagent for the preparation of indole cPLA2α inhibitors, which are important in the development of drugs targeting inflammatory and other diseases.
Used in Organic Synthesis:
3-Cyanopropionaldehyde Diethyl Acetal is used as a starting reagent in the synthesis of various organic compounds, such as methyl 2-(3,3-diethoxypropyl)-5-methoxyoxazole-4-carboxylate and tert-butyl 2-(3,3-diethoxypropyl)-5-tert-butoxyoxazole-4-carboxylate. It is also used in the synthesis of spermidine derivatives, which have potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 18381-45-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,8 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18381-45:
(7*1)+(6*8)+(5*3)+(4*8)+(3*1)+(2*4)+(1*5)=118
118 % 10 = 8
So 18381-45-8 is a valid CAS Registry Number.
InChI:InChI=1S/C8H15NO2/c1-3-10-8(11-4-2)6-5-7-9/h8H,3-6H2,1-2H3
18381-45-8Relevant articles and documents
Total synthesis of (+)-galbulin and unnatural lignans
Clausen, Florian,Studer, Armido
supporting information, p. 6780 - 6783 (2020/09/15)
The total synthesis of (+)-galbulin was achieved in 15% yield and 99% ee over eight steps from commercially available 4-veratraldehyde. The key steps include Meyer's asymmetric tandem addition to a chiral 2-oxazoline-substituted naphthalene, a Pd-catalyzed stereospecific decarboxylative γ-arylation, and a formal anti-Markovnikov hydromethylation. In addition, five unnatural lignans were synthesized using the same synthetic strategy.
