183866-66-2

Basic information

• Product Name: (R)-3-Eth-(Z)-ylidene-4-(1H-indol-2-ylmethyl)-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 183866-66-2
• Molecular Weight: 374.483
• Mol File: 183866-66-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-Eth-(Z)-ylidene-4-(1H-indol-2-ylmethyl)-piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Eth-(Z)-ylidene-4-(1H-indol-2-ylmethyl)-piperidine-1-carboxylic acid benzyl ester(183866-66-2)
• EPA Substance Registry System: (R)-3-Eth-(Z)-ylidene-4-(1H-indol-2-ylmethyl)-piperidine-1-carboxylic acid benzyl ester(183866-66-2)

Safety Data

• Hazardous Substances Data: 183866-66-2(Hazardous Substances Data)

Upstream product

• 27854-86-0 (1R)-1-(3-pyridyl)ethyl acetate 
• 5096-11-7 (R)-1-(3-pyridyl)ethanol 
• 4754-27-2 1-(3-Pyridyl)ethanol 
• 350-03-8 methyl-3-pyridylketone 
• 183866-61-7 5-((R)-1-Hydroxy-ethyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 72504-66-6 (1R)-1-(1-benzyl-1,2,5,6-tetrahydro-3-pyridyl)ethanol 
• 82185-43-1 N-(trimethylsilyl)-o-toluidine 
• 183866-63-9 (R,Z)-benzyl 3-ethylidene-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate 

Relevant articles and documents

An enantioselective synthesis of the Strychnos alkaloid (-)-tubifoline

An enantioselective synthesis of the Strychnos alkaloid (-)-tubifoline, involving the kinetic resolution of racemic 1-(3-pyridyl)ethanol, the orthoester Claisen rearrangement of the enantiopure allylic alcohol 5, Smith indolization of the resulting 4-piperidineacetate 6, photocyclization of chloroacetamide 9, and final transannular cyclization, is reported.