18387-92-3 Usage
Description
2-(TRIMETHYLSILYL)-5-METHYLTHIOPHENE is a chemical compound that belongs to the family of organosilicon compounds. It is a derivative of thiophene, which is a five-membered heterocyclic compound consisting of four carbon atoms and one sulfur atom. The trimethylsilyl group is a common functional group in organosilicon chemistry, and it is used as a protecting group for alcohols and a synthetic intermediate for various organic reactions.
Uses
Used in Organic Synthesis:
2-(TRIMETHYLSILYL)-5-METHYLTHIOPHENE is used as a synthetic intermediate for the synthesis of various organic compounds. Its reactivity and functional group compatibility make it a valuable building block in the preparation of complex organic molecules.
Used in Pharmaceutical Industry:
2-(TRIMETHYLSILYL)-5-METHYLTHIOPHENE is used as a key component in the development of pharmaceutical compounds. Its unique structure and properties allow it to be incorporated into drug molecules, potentially leading to the discovery of new therapeutic agents.
Used in Material Science:
2-(TRIMETHYLSILYL)-5-METHYLTHIOPHENE can be used in the development of new materials with specific properties, such as electronic devices, sensors, and advanced materials for various applications. Its organosilicon nature and thiophene-based structure contribute to its potential use in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 18387-92-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,8 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 18387-92:
(7*1)+(6*8)+(5*3)+(4*8)+(3*7)+(2*9)+(1*2)=143
143 % 10 = 3
So 18387-92-3 is a valid CAS Registry Number.
18387-92-3Relevant articles and documents
THE RATES OF BASE CLEAVAGE OF SUBSTITUTED 2-THIENYLTRIMETHYLSILANES. AB INITIO CALCULATIONS OF THE ACIDITIES OF MONOSUBSTITUTED THIOPHENS
Seconi, Giancarlo,Eaborn, Colin,Stamper, John G.
, p. 153 - 168 (2007/10/02)
Rates of cleavage in NaOMe-MeOH at 50 deg C have been determined for the mono-substituted 2-trimethylsilylthiophens X*C4H2S*SiMe3-2 with X = H, 3-NO2, 3-Br, 4-Br-, and 5-NO2, -CN, -COPh, -Me, -OMe and -NMe2, and for one disubstituted compound, 4,5-Br2*C4HS*SiMe3-2.For several compounds the rate and product isotope effects have also been determined.The energies involved in the process X*C4H3S X*C4H2S- for deprotonation at the 2-position have been calculated by an ab initio method (STO-3G), and the results used in analysis of the substituent effects in the cleavage of the XC4H2S*SiMe3-2 compounds.The results are consistent with the view the aryl anions separate in the rate-determining step of the cleavage.The isotope effects are all close to unity, whereas by comparison with results for XC6H4CH2SiMe3 and related species of similar reactivity, values in the region of 10 would be expected for the 3- and 5-NO2 compounds if the product isotope effect for a carbanion R depended only in the pKa of RH.The difference between the thienyl- and benzyl-type anions is attributed to the absence of conjugative delocalization of the charge in the former. Approximate pKa values are derived for the 2-positions of the X*C4H3S compounds.