1841-57-2

Basic information

• Product Name: 4'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID
• Synonyms: CHEMBRDG-BB 4400445;4'-FLUORO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;4'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID;AKOS BAR-0167;2-BIPHENYL-4'-FLUORO-CARBOXYLIC ACID;2-(4-FLUOROPHENYL)BENZOIC ACID;RARECHEM AL BE 1235;4'-fluorobiphenyl-2-carboxylic acid(SALTDATA: FREE)
• CAS NO: 1841-57-2
• Molecular Formula: C₁₃H₉FO₂
• Molecular Weight: 216.21
• Mol File: 1841-57-2.mol
• Article Data: 19

Chemical Properties

• Melting Point: >225 °C
• Boiling Point: 340.9 °C at 760 mmHg
• Flash Point: 160 °C
• Appearance: /
• Density: 1.261 g/cm³
• PKA: 3.83±0.36(Predicted)
• CAS DataBase Reference: 4'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID(1841-57-2)
• EPA Substance Registry System: 4'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID(1841-57-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1841-57-2(Hazardous Substances Data)

Usage

General Description

4'-Fluoro-biphenyl-2-carboxylic acid is a chemical compound that consists of a biphenyl core with a carboxylic acid functional group and a fluorine atom attached to one of its aromatic rings. It is a white crystalline solid with a molecular formula of C13H9FO2 and a molecular weight of 216.21 g/mol. 4'-FLUORO-BIPHENYL-2-CARBOXYLIC ACID is used in organic synthesis and as a building block in the production of various pharmaceuticals, agrochemicals, and advanced materials. It is also used as a research tool in the development of new chemical reactions and processes. Additionally, 4'-fluoro-biphenyl-2-carboxylic acid may have potential applications in the fields of medicinal chemistry and drug discovery.

Upstream product

• 343-01-1 2-fluoro-9H-fluoren-9-one 
• 80254-82-6 methyl 4'-fluoro-[1,1'-biphenyl]-2-carboxylate 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 1765-93-1 4-fluoroboronic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 352-34-1 4-fluoro-1-iodobenzene 
• 65-85-0 benzoic acid 
• 59247-52-8 isopropyl o-bromobenzoate 
• 88-65-3 2-bromobenzoic-acid 
• 1829-28-3 ethyl 2-iodobenzoate 
• 88-67-5 2-Iodobenzoic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 653589-95-8 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester 
• 773138-83-3 4'-fluoro-[1,1'-biphenyl]-2-carboxylic acid ethyl ester 

Downstream Products

• 7509-00-4 3-fluoro-6H-benzo[c]chromen-6-one 
• 343-43-1 2-fluoro-9H-fluorene 
• 343-01-1 2-fluoro-9H-fluoren-9-one 
• 408366-07-4 2-[(4-{(tert-Butoxycarbonyl)[2-(2-pyridinyl)ethyl]amino}anilino)carbonyl]-4'-fluoro-1,1'-biphenyl 
• 897446-33-2 4'-fluorobiphenyl-2-carboxylic acid (2-aminophenyl)amide 

Relevant articles and documents

New electron-accepting quinoxalinothiadiazole-containing heterocycles as promising building blocks for organic optoelectronic devices

Two novel quinoxalinothiadiazole-containing dibromides—4,9-dibromo-6,7-bis(9,9-didodecyl7-fluoro-9H-fluoren-2-yl)[1,2,5]thiadiazolo[3,4-g]quinoxaline (11) and 4,9-dibromo-6,7-bis(9,9-didodecyl-5,7-difluoro-9H-fluoren-2-yl)[1,2,5]thiadiazolo[3,4-g]quinoxaline (19)—have been synthesized, which are promising strong electron-accepting building blocks for preparing highly efficient narrow-bandgap D–A conjugated polymers. The composition and structure of monomers 11 and 19 have been proved by elemental analysis data, IR spectroscopy, and 1H and 13C NMR.

Mechanochemical-Cascaded C-N Cross-Coupling and Halogenation Using N-Bromo- And N-Chlorosuccinimide as Bifunctional Reagents

Exploration of alternative energy sources for chemical transformations has gained significant interest from chemists, and mechanochemistry is one of those sources. Herein, we report the use of N-bromosuccinimides (NBS) and N-chlorosuccinimides (NCS) as bifunctional reagents for a cascaded C-N bond formation and subsequent halogenation reactions. Under the solvent-free mechanochemical (ball-milling) conditions, the synthesis of a wide range of phenanthridinone derivatives from N-methoxy-[1,1′-biphenyl]-2-carboxamides is accomplished. During the reactions, NBS and NCS first assisted the oxidative C-N coupling reaction and subsequently promoted a halogenation reaction. Thus, the role of NBS and NCS was established to be bifunctional. Overall, a mild, solvent-free, convenient, one-pot, and direct synthesis of various bromo- and chloro-substituted phenanthridinone derivatives was achieved.

Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.