18410-18-9

Basic information

• Product Name: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one
• Synonyms: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one;5-(4-Chlorophenyl)-3,4-dihydro-2(5H)-furanone;5-(4-Chlorophenyl)-4,5-dihydro-2(3H)-furanone;5-(4-Chlorophenyl)-4,5-dihydrofuran-2(3H)-one;Einecs 242-292-4
• CAS NO: 18410-18-9
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.63026
• EINECS: 242-292-4
• Mol File: 18410-18-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 357.2°Cat760mmHg
• Flash Point: 193.2°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 2.77E-05mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one(18410-18-9)
• EPA Substance Registry System: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one(18410-18-9)

Safety Data

• Hazardous Substances Data: 18410-18-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9ClO2/c11-8-3-1-7(2-4-8)9-5-6-10(12)13-9/h1-4,9H,5-6H2

Upstream product

• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 7148-01-8 methyl 4-(4-chlorophenyl)-4-oxobutanoate 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 80552-14-3 C₁₀H₁₁ClO₃ 
• 99-91-2 para-chloroacetophenone 
• 29582-39-6 3-(4-chlorobenzoyl)acrylic acid 
• 14506-33-3 1-(4-chlorophenyl)but-3-en-1-ol 
• 137575-62-3 1-(4’-chlorophenyl)butan-1,4-diol 
• 102058-50-4 5-(4'-chlorophenyl)-1-penten-5-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 42249-99-0 1-(4-chlorophenyl)but-3-yn-1-ol 
• 1073-67-2 4-vinylbenzyl chloride 
• 108-24-7 acetic anhydride 
• 108-90-7 chlorobenzene 

Downstream Products

• 36159-73-6 4-(p-chlorophenyl)-1-tetralone 
• 79559-98-1 [(1R,4R)-4-(4-Chloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine; hydrochloride 
• 4521-17-9 dihydro-5-(4-chlorophenyl)-2(3H)-thiophenone 
• 4103-56-4 ethyl trans-2-(4-chlorophenyl)cyclopropane-1-carboxylate 
• 4157-47-5 (±)-trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid 
• 137575-62-3 1-(4’-chlorophenyl)butan-1,4-diol 
• 100117-11-1 4-Chlor-4-(4-chlor-phenyl)-buttersaeureethylester 

Relevant articles and documents

Efficient hydrogenation of levulinic acid catalysed by spherical NHC-Ir assemblies with atmospheric pressure of hydrogen

A practical, efficient, and mild hydrogenation of levulinic acid (LA) to γ-valerolactone (GVL) under 1 atm H2was realized by single-sited 3D porous self-supported N-heterocyclic carbene iridium catalysts. Quantitative yields and selectivities were achieved at 0.02 mol% catalyst loading, and the catalyst could be reused for 9 runs without obvious loss of selectivity or activity.

One-Pot γ-Lactonization of Homopropargyl Alcohols via Intramolecular Ketene Trapping

A one-pot γ-lactonization of homopropargyl alcohols via an alkyne deprotonation/boronation/oxidation sequence has been developed. Oxidation of the generated alkynyl boronate affords the corresponding ketene intermediate, which is trapped by the adjacent hydroxy group to furnish the γ-lactone. We have optimized the conditions as well as examined the substrate scope and synthetic applications of this efficient one-pot lactonization.

Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids

A new method for the formation of γ- and δ-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced by visible light and relies on a mild cooperative catalysis by the combination of molecular iodine and an organic dye.