184229-68-3Relevant articles and documents
Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form
Henningfeld, Kristine A.,Arslan, Tuncer,Hecht, Sidney M.
, p. 11701 - 11714 (2007/10/03)
DNA ligation by DNA topoisomerase I was investigated employing synthetic DNA substrates containing a single strand nick. Site-specific cleavage of the DNA by topoisomerase I in proximity to the nick resulted in uncoupling of the cleavage and ligation reac