18428-80-3

Basic information

• Product Name: 2-Propen-1-one, 1,3-bis(4-hydroxy-3-methoxyphenyl)-
• CAS NO: 18428-80-3
• Molecular Formula: C17H16O5
• Molecular Weight: 300.311
• Mol File: 18428-80-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1,3-bis(4-hydroxy-3-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1,3-bis(4-hydroxy-3-methoxyphenyl)-(18428-80-3)
• EPA Substance Registry System: 2-Propen-1-one, 1,3-bis(4-hydroxy-3-methoxyphenyl)-(18428-80-3)

Safety Data

• Hazardous Substances Data: 18428-80-3(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Relevant articles and documents

Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation

A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found

Anti-oxidant activities of curcumin and related enones

The natural product curcumin (diferuloylmethane, 1,7-bis(4-hydroxy-3- methoxyphenyl)-1,6-heptadiene-3,5-dione), obtained from the spice turmeric, exhibits numerous biological activities including anti-cancer, anti-inflammatory, and anti-angiogenesis activities. Some of these biological activities may derive from its anti-oxidant properties. There are conflicting reports concerning the structural/electronic basis of the anti-oxidant activity of curcumin. Curcumin is a symmetrical diphenolic dienone. A series of enone analogues of curcumin were synthesized that included: (1) curcumin analogues that retained the 7-carbon spacer between the aryl rings; (2) curcumin analogues with a 5-carbon spacer; and (3) curcumin analogues with a 3-carbon spacer (chalcones). These series included members that retained or were devoid of phenolic groups. Anti-oxidant activities were determined by the TRAP assay and the FRAP assay. Most of the analogues with anti-oxidant activity retained the phenolic ring substituents similar to curcumin. However, a number of analogues devoid of phenolic substituents were also active; these non-phenolic analogues are capable of forming stable tertiary carbon-centered radicals.