18430-91-6

Basic information

• Product Name: 1-(2-hydroxyphenyl)pentan-1-one
• Synonyms: 1-(2-Hydroxyphenyl)pentan-1-one; 1-pentanone, 1-(2-hydroxyphenyl)-
• CAS NO: 18430-91-6
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Mol File: 18430-91-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 271°Cat760mmHg
• Flash Point: 113°C
• Appearance: /
• Density: 1.055g/cm³
• Vapor Pressure: 0.00399mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 1-(2-hydroxyphenyl)pentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyphenyl)pentan-1-one(18430-91-6)
• EPA Substance Registry System: 1-(2-hydroxyphenyl)pentan-1-one(18430-91-6)

Safety Data

• Hazardous Substances Data: 18430-91-6(Hazardous Substances Data)

Usage

Description

1-(2-hydroxyphenyl)pentan-1-one, also known as 1-phenyl-2-hydroxy-1-pentanone, is a chemical compound that belongs to the class of ketones. It is a colorless to pale yellow liquid with a sweet, floral odor. 1-(2-hydroxyphenyl)pentan-1-one is known for its antioxidant properties and potential applications in various industries.

Uses

Used in Cosmetic and Personal Care Industry:
1-(2-hydroxyphenyl)pentan-1-one is used as a fragrance ingredient for its sweet, floral scent, enhancing the sensory experience of various cosmetic and personal care products.
Used in Pharmaceutical Industry:
1-(2-hydroxyphenyl)pentan-1-one is used as an anti-inflammatory and anti-cancer agent due to its potential therapeutic effects, which are currently being studied for their efficacy in treating inflammation and cancer.
Used in Chemical Formulations:
1-(2-hydroxyphenyl)pentan-1-one is used as a stabilizer in certain formulations, leveraging its antioxidant properties to prevent degradation and extend the shelf life of products.

InChI:InChI=1/C11H14O2/c1-2-3-7-10(12)9-6-4-5-8-11(9)13/h4-6,8,13H,2-3,7H2,1H3

Upstream product

• 109-72-8 n-butyllithium 
• 1433-61-0 2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one 
• 109-65-9 1-bromo-butane 
• 119-36-8 methyl salicylate 
• 90-02-8 salicylaldehyde 
• 106-99-0 buta-1,3-diene 
• 870010-43-8 2-(pent-1-yn-1-yl)phenol 
• 24635-48-1 chloro(butyl)diphenylsilane 
• 19311-91-2 N,N-diethylsalicylamide 
• 995-45-9 tributylchlorosilane 
• 108-95-2 phenol 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 1009-14-9 phenyl butyl ketone 
• 611-20-1 salicylonitrile 

Downstream Products

• 1359967-07-9 11-butyl-6,7,8,9,10,11-hexahydro-6,11-epoxydibenzo[b,e]oxepine 
• 1359967-04-6 2-(1-butyl-3-methoxy-1,3,4,5,6,7-hexahydroisobenzofuran-1-yl)phenol 
• 1359967-08-0 C₂₀H₃₀O₄ 
• 1270412-14-0 2-(1-aminopentyl)phenol 
• 21326-84-1 N-butylbenzo[d]oxazol-2-amine 
• 6797-49-5 2-butylbenzo[d]oxazole 
• 63462-45-3 1-[2-(2,4-Dichloro-benzyloxy)-phenyl]-pentan-1-ol 
• 17508-89-3 4,6-Dinitro-2-(1-butylheptyl)-phenol 
• 17508-84-8 4,6-Dinitro-2-(1-butylpentyl)-phenol 
• 17404-53-4 2-(1-Butylheptyl)-phenol 
• 17404-48-7 2-(1-Butylpentyl)-phenol 
• 89423-49-4 (R)-o-<1-((S)-1-α-naphthylethylamino)pentyl>phenol 
• 77383-01-8 (S)-o-<1-((S)-1-α-naphthylethylamino)pentyl>phenol 
• 71289-75-3 1-[2-(2,4-Dichloro-benzyloxy)-phenyl]-pentan-1-one 

Relevant articles and documents

Nucleophilic addition reaction with dearomatization of naphthalene ring

Various aromatic lactones have been synthesized and their regioselectivity (1,2-addition vs. 1,4- or 1,6-addition) investigated in reactions with organolithium species, particularly n-BuLi and sec-BuLi. The regioselectivity varied greatly depending on various factors, such as the bulkiness of both substrates and organolithium species, and types of solvent and cosolvent. In particular, 1,4-addition with dearomatization occurred preferentially using sec-BuLi as the nucleophile in tetrahydrofuran (THF) with hexamethylphosphoramide (HMPA) or N,N′-dimethylpropyleneurea (DMPU) as cosolvent. For sec-BuLi, the reaction was estimated to proceed through a single-electron transfer mechanism.

Rhodium-Catalyzed Annulations of 1,3-Dienes and Salicylaldehydes/2-Hydroxybenzyl Alcohols Promoted by 2-Ethylacrolein

A rhodium-catalyzed 2-ethylacrolein-promoted protocol enables the annulation reactions of 1,3-dienes with either salicylaldehydes or 2-hydroxybenzyl alcohols leading to 2-alkylchroman-4-ones with high regioselectivity. This research highlights the use of 2-ethylacrolein which probably serves as a tool of bidentate coordination to rhodium intermediates. Mechanistic studies reveal that the transformation proceeds through the 1,4-hydroacylation pathway to access unsaturated linear ketones with subsequent oxo-Michael addition. (Figure presented.).

THIOSEMICARBAZONES INHIBITORS OF LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE AND USES THEREOF

Lysophosphatidic acid acyltransferase-beta (LPAAT-β) catalyzes the production of phosphatidic acid (PA) from lysophosphatidic acid (LPA). The lipid cofactor PA contributes to the activation of c-Raf, BRAF, mTOR and PKC-ζ. LPAAT-β expression is a prognostic factor in gynecologic malignancies and is being investigated as a therapeutic target in a variety of tumor types. A class of thiosemicarbazones was identified as inhibitors of LPAAT-β from a screen of a library of small molecules. A focused library of thiosemicarbazones derivatives was prepared and led to the development of compounds which potently inhibit LPAAT-β and inhibit the growth of MiaPaCa2 human pancreatic cancer cells.