18435-67-1

Basic information

• Product Name: {2-[2-(methoxycarbonyl)phenyl]-2-oxoethylidene}diazenium
• CAS NO: 18435-67-1
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 205.1895
• Mol File: 18435-67-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: {2-[2-(methoxycarbonyl)phenyl]-2-oxoethylidene}diazenium(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[2-(methoxycarbonyl)phenyl]-2-oxoethylidene}diazenium(18435-67-1)
• EPA Substance Registry System: {2-[2-(methoxycarbonyl)phenyl]-2-oxoethylidene}diazenium(18435-67-1)

Safety Data

• Hazardous Substances Data: 18435-67-1(Hazardous Substances Data)

Usage

Description

2-[2-(methoxycarbonyl)phenyl]-2-oxoethylidenediazenium, also known as Molsidomine, is a chemical compound with nitric oxide (NO) donor properties. It is a vasodilator used in the treatment of angina pectoris and heart failure, working by releasing nitric oxide to relax blood vessels and increase blood flow to the heart.

Uses

Used in Cardiovascular Applications:
Molsidomine is used as a vasodilator for the treatment of angina pectoris and heart failure. It functions by releasing nitric oxide, which relaxes blood vessels and enhances blood flow to the heart, thereby reducing the workload on the heart and improving oxygen delivery to the myocardium.
Used in Erectile Dysfunction Treatment:
Molsidomine is being studied for its potential use in treating erectile dysfunction. As a nitric oxide donor, it may help improve blood flow to the penile tissues, aiding in achieving and maintaining an erection.
Used in Pulmonary Hypertension Treatment:
Molsidomine has shown promising results in improving exercise capacity and quality of life in patients with pulmonary hypertension. It is being investigated for its potential to treat this condition by enhancing blood flow and reducing the workload on the heart.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Molsidomine is utilized as an active ingredient in the development of drugs targeting cardiovascular diseases, erectile dysfunction, and pulmonary hypertension. Its NO donor properties make it a valuable compound for creating medications that can improve blood flow and reduce the strain on the heart.

Upstream product

• 4376-18-5 Monomethyl phthalate 
• 186581-53-3 diazomethane 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 

Downstream Products

• 142822-78-4 C₂₇H₂₀N₂O₈S 
• 142822-79-5 C₂₇H₂₀N₂O₈S 
• 142822-80-8 C₃₇H₂₈N₂O₁₁S 
• 5693-27-6 isochroman-1,4-dione 
• 14505-49-8 3-methyl-isochroman-1,4-dione 

Relevant articles and documents

Regio- and Diastereoselective Dimerization of Diazo Carbonyls: A Cooperative Catalytic Approach to Complex Scaffolds with Four Contiguous Stereocenters

Starting from readily available o-diazoacyl-substituted arene carboxylates, scaffolds with the 5,9-epoxycyclohepta[b]pyran-2(3H)-one core were obtained by cooperative RhII, Lewis and Br?nsted acid catalysis. Four new bonds, three functional gro

Efficient construction of the oxatricyclo[6.3.1.00,0]dodecane core of komaroviquinone using a cyclization/cycloaddition cascade of a rhodium carbenoid intermediate

(Chemical Equation Presented) The rhodium(II)-catalyzed cyclization/cycloaddition cascade of a o-carbomethoxyaryl diazo dione is described as a potential route to the oxatricyclo[6.3.1.00.0]dodecane substructure of the icetexane diterpene komar

INTRAMOLECULAR ACID-CATALYZED REACTIONS OF o-CARBOMETHOXY-ω-DIAZOACETOPHENONES

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