18439-24-2 Usage
Description
Coenzyme A trilithium salt, also known as CoA-SH, is a vital cofactor involved in numerous enzymatic acetyl transfer reactions. It is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and acts as the master regulator in various biochemical processes. Coenzyme A trilithium salt is characterized by its beige crystal form and plays a crucial role in the functioning of proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase by providing the phosphopantetheine group as a prosthetic group.
Uses
Used in Enzymatic Acetyl Transfer Reactions:
Coenzyme A trilithium salt is used as a cofactor in enzymatic acetyl transfer reactions, facilitating the transfer of acetyl groups between molecules and playing a key role in various metabolic pathways.
Used in Standard Curve Generation:
In the kinetic assay of acetyltransferase Gcn5 acylation, Coenzyme A trilithium salt is utilized for generating a standard curve, which helps in determining the enzyme activity and understanding the underlying mechanisms of the acetyltransferase reaction.
Used in Cofactor for JNADH and JNADPH Production Assay:
Coenzyme A trilithium salt serves as a cofactor in the production assay of JNADH and JNADPH, which are essential cofactors in various redox reactions and electron transport chains within cells.
Used in Labeling of Alexa647 (AF647) Probe:
In the labeling of Alexa647 (AF647) probe, Coenzyme A trilithium salt is employed to enhance the fluorescence properties of the probe, allowing for better detection and visualization in various biological applications.
Used in Biochemical Research:
Coenzyme A trilithium salt is widely used in biochemical research to study the mechanisms of enzymatic reactions, investigate the role of acetyl groups in cellular processes, and develop new therapeutic strategies targeting acetyl transfer enzymes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Coenzyme A trilithium salt is utilized in the development of drugs targeting metabolic disorders and diseases related to acetyl transfer reactions, such as obesity, diabetes, and neurodegenerative disorders.
Used in Diagnostic Applications:
Coenzyme A trilithium salt can be employed in diagnostic applications to detect and measure the activity of acetyltransferase enzymes, which can be indicative of certain diseases or disorders.
Used in Food Industry:
In the food industry, Coenzyme A trilithium salt may be used as a supplement or additive to enhance the metabolic processes and improve the nutritional value of food products.
Overall, Coenzyme A trilithium salt is a versatile and essential compound with applications spanning across various industries, including enzymatic reactions, biochemical research, pharmaceutical development, diagnostic applications, and the food industry. Its role as a cofactor in acetyl transfer reactions and its involvement in numerous metabolic pathways make it a valuable asset in understanding and manipulating biological processes for various applications.
Biochem/physiol Actions
Coenzyme A is a ubiquitous cofactor, synthesized from pantothenic acid through a ATP dependent reaction. It plays a vital role in tricarboxylic acid cycle, metabolism of short- and long-chain fatty acids. In addition, it also aids in synthesis of phospholipids and cell growth.
Check Digit Verification of cas no
The CAS Registry Mumber 18439-24-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,3 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18439-24:
(7*1)+(6*8)+(5*4)+(4*3)+(3*9)+(2*2)+(1*4)=122
122 % 10 = 2
So 18439-24-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16+,20-;;;/m1.../s1
