184473-59-4

Basic information

• Product Name: 4-bromo-2,5-dimethoxyphenylacetic acid
• Synonyms: 4-bromo-2,5-dimethoxyphenylacetic acid
• CAS NO: 184473-59-4
• Molecular Weight: 275.099
• Mol File: 184473-59-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-bromo-2,5-dimethoxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2,5-dimethoxyphenylacetic acid(184473-59-4)
• EPA Substance Registry System: 4-bromo-2,5-dimethoxyphenylacetic acid(184473-59-4)

Safety Data

• Hazardous Substances Data: 184473-59-4(Hazardous Substances Data)

Upstream product

• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 446831-24-9 1-bromo-4-chloromethyl-2,5-dimethoxy-benzene 
• 143-33-9 sodium cyanide 

Downstream Products

• 184473-60-7 2-(4-bromo-2,5-dimethoxyphenyl)ethanol 
• 184473-61-8 2,5-dihydroxy-4-bromophenethylbromide 
• 40492-53-3 2,3-dihydro-6-bromo-5-hydroxybenzofuran 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 

Relevant articles and documents

One-pot Claisen rearrangement/O-methylation/alkene isomerization in the synthesis of ortho-methoxylated phenylisopropylamines

An improved synthesis of a potent serotonin agonist 1a and its novel derivative 1b is described, making use of a Claisen rearrangement whose unstable phenolic product is methylated and isomerized in situ. This method may be of general use in the synthesis of α-methoxylated phenethylamine derivatives. The synthesis also includes an unusual, one pot demethylation/primary alcohol bromination with boron tribromide.