18456-45-6

Basic information

• Product Name: 4H-Thiopyran-4-one, tetrahydro-2,6-diphenyl-, trans-
• CAS NO: 18456-45-6
• Molecular Formula: C17H16OS
• Molecular Weight: 268.379
• Mol File: 18456-45-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4H-Thiopyran-4-one, tetrahydro-2,6-diphenyl-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Thiopyran-4-one, tetrahydro-2,6-diphenyl-, trans-(18456-45-6)
• EPA Substance Registry System: 4H-Thiopyran-4-one, tetrahydro-2,6-diphenyl-, trans-(18456-45-6)

Safety Data

• Hazardous Substances Data: 18456-45-6(Hazardous Substances Data)

Upstream product

• 35225-79-7 dibenzylideneacetone 
• 18456-44-5 cis-2,6-Diphenyltetrahydrothiopyran-4-on 
• 100-52-7 benzaldehyde 
• 538-58-9 1,5-diphenyl-1,4-pentadiene-3-one 
• 103225-43-0 2,3,5,6-Tetrahydro-2,6-diphenylthiopyran-4-one 1,1-dioxide 
• 65628-16-2 (2S,6S)-4-Hydroxy-2,6-diphenyl-tetrahydro-thiopyran-4-carbonitrile 
• 6287-64-5 1,5-Diphenyl-1,4-pentadien-3-one 

Downstream Products

• 40604-21-5 (+/-)-trans-4-Methyl-2,6-diphenyl-3,6-dihydro-2H-thiopyran 
• 65628-16-2 (2S,6S)-4-Hydroxy-2,6-diphenyl-tetrahydro-thiopyran-4-carbonitrile 
• 90382-89-1 trans-5,7-diphenyl-1-oxa-6-thiaspiro<2.5>octane 
• 18456-44-5 cis-2,6-Diphenyltetrahydrothiopyran-4-on 
• 34379-72-1 trans-2,3,5,6-Tetrahydro-2,6-diphenylthiopyran-4-one 1,1-dioxide 
• 18458-70-3 4tMethyl-2r,6c-diphenyl-tetrahydro-thiopyran-4c-ol 
• 28285-60-1 1-oxo-2,6-diphenyl-tetrahydro-1λ⁴-thiopyran-4-one 
• 37123-03-8 2,4,6,8-tetraphenyl-3-thia-7-aza-bicyclo[3.3.1]nonan-9-one 

Relevant articles and documents

Diastereoselective synthesis of 2,6-diaryltetrahydrothiopyran-4-ones by phase-transfer catalysis

Two efficient phase-transfer-catalyzed protocols for the diastereoselective synthesis of cis and trans isomers of 2,6-diaryltetrahydrothiopyran-4-ones (2,6-DATHTPs) have been developed. In a study of the scope of the reactions, differently substituted 2,6

Synthesis, spectral, crystal and antimicrobial studies of biologically potent oxime ethers of nitrogen, oxygen and sulfur heterocycles

Three series of oxime ethers viz, 2,6-diarylpiperidin-4-one O-benzyloximes 5a-o, 2,6-diaryltetrahydropyran-4-one O-benzyloximes 7a-e and 2,6-diaryltetrahydrothiopyran-4-one O-benzyloximes 11a-b and 12a-c were synthesized and stereochemistry is established by their spectral and single crystal analysis. A SAR study has been carried out for the above oxime ethers against a panel of antibacterial (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Escherichia coli) and antifungal agents (Candida albicans, Candida-51, Rhizopus sp., Aspergillus niger, Aspergillus flavus and Cryptococcus neoformans), respectively, using Ciprofloxacin and Amphotericin B as standards. Most of the chloro/methyl/methoxy substituted compounds exerted moderate to good activity against all the tested organisms; moreover, some compounds (5i, 5l, 5n, 5o, 7c2, 7d1, 7d2, 7e, 11b and 12c) exhibited promising activity than standard drugs.

Phase Transfer-Catalyzed Reactions between Polysulfide Anions and α,β-Unsaturated Carbonyl Compounds

Ammonium polysulfide reacts with α,β-unsaturated ketones and aldehydes under PTC (phase transfer catalysis) conditions in a rather different manner than it does in homogeneous systems. 1,3-Diphenyl-2-propen-1-one (chalcone, 1) and 4-phenyl-3-buten-2-one (